Osmotic drug delivery system

• US 4,475,916 A
• Filed: 03/18/1982
• Issued: 10/09/1984
• Est. Priority Date: 03/18/1982
• Status: Expired due to Term

• Current Assignee: Merck and Company Incorporated Lincoln Avenue Rahway NJ
• Original Assignee: Merck & Co., Inc.
• Inventors: Himmelstein, Kenneth J.
• Primary Examiner(s): Padgett, Benjamin R.
• Assistant Examiner(s): Wallen, T. J.
• Application Number:
  US06/359,324
• Time in Patent Office: 936 Days
• Field of Search: 604/890-900, 424/18-25, 128/127-132
• US Class Current: 424/424
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic drug (or other beneficial substance) delivery system comprises a compartment with one or more chambers in series formed by an external shell and chamber-dividing walls of a microporous material and successive overlayers of semipermeable membranes completely covering the outer shell of all but one chamber and substantially covering the outer shell of that one chamber, each successive overlayer completely covering all but one more chamber and substantially covering that one more chamber. Osmotic agents, adjuvants, enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chambers covered by the semipermeable membranes, and external fluids that diffuse into that chamber form solutions and by osmotic pressure are forced through the microporous chamber-dividing wall to the drug or drug-forming chamber to form a solution thereof and then through the exposed microporous shell to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.

Claims

1. An osmotic delivery system shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of at least one chamber, said chamber being adapted to house osmotically active agents, adsorption adjuvants, drugs, and pro-drugs, said chamber being formed by an external shell of a rigid microporous material;

and at least one overlayer of a semipermeable membrane substantially covering the external shell of said chamber leaving exposed a microporous drug-emitting surface.

2. The osmotic delivery system of claim 1, wherein said compartment consists of at least two chambers in series with chamber-dividing walls of a rigid microporous material, wherein said overlayer consists of at least two successive overlayers of a semipermeable membrane, the first overlayer completely covering the external shell of all but one chamber and substantially covering the external shell of that one chamber leaving exposed a microporous drug-emitting surface;

and each successive overlayer completely covering all but one more chamber and substantially covering that one more chamber.

3. The osmotic delivery system of claim 2 shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment with 1 chamber or, 2 or 3 chambers in series, the chambers being adapted to house osmotically active agents, adsorption adjuvants, drugs, and pro-drugs.

4. The osmotic delivery system of claim 2 shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of 3 chambers in series, the chambers being adapted to house osmotically active agents, adsorption adjuvants, drugs, and pro-drugs.

5. The osmotic delivery system of claim 2 shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of 2 chambers in series, the chambers being adapted to house osmotically active agents, adsorption adjuvants, drugs, and pro-drugs.

6. The osmotic delivery system of claim 1 shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other beneficial substance comprising a compartment consisting of 1 chamber, the chamber being adapted to house osmotically active agents, adsorption adjuvants, drug, and pro-drugs.

7. The delivery system of claim 2, comprising 2 chambers wherein the first chamber is adapted to house an osmotically active agent and the second chamber is adapted to house a drug or other beneficial substance.

8. The delivery system of claim 2 comprising 3 chambers wherein the first chamber is adapted to house a composition comprising an absorption adjuvant, the middle chamber is adapted to house a composition comprising an osmotically active agent and the third chamber is adapted to house a composition comprising a drug or other beneficial substance.

9. The osmotic delivery system of claim 1, further comprising a quick release loading dose of drug external to and covering said microporous drug-emitting surface.

10. The osmotic delivery system of claim 1, further comprising a cap covering said drug-emitting surface designed for spontaneous removal following establishment of desired flow characteristics.

11. The osmotic delivery system of claim 1, wherein said microporous material and said semipermeable membrane is a cellulose acetate.