Preparations containing methylsulfonylmethane and methods of use and purification

• US 4,477,469 A
• Filed: 06/26/1981
• Issued: 10/16/1984
• Est. Priority Date: 08/30/1979
• Status: Expired due to Term

• Current Assignee: Robert J. Herschler
• Original Assignee: Robert J. Herschler
• Inventors: Herschler, Robert J.
• Primary Examiner(s): Friedman, Stanley J.
• Application Number:
  US06/277,592
• Time in Patent Office: 1,208 Days
• Field of Search: 424/322
• US Class Current: 514/588
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/7004 Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations
• CPC Class Codes: A61Q 3/02 Nail coatings
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring

Abstract

Preparations containing methylsulfonylmethane (MSM) for administration to the skin, nails, other tissue and/or body fluids of a human or other animal subject are disclosed. Such compositions soften skin, strengthen nails and provide other benefits when applied topically. And, MSM compositions may also be administered orally, by injection and by inhalation.

In many instances, the effectiveness of MSM compositions is enhanced when such compositions contain carbamide (urea). Also, carbamide compositions are stabilized when they contain the MSM.

For topical administration, MSM compositions may be formulated in creams, lotions or gels which may be used alone or to serve as stable, neutral vehicles for other skin conditioning substances or therapeutically active drugs. Aqueous MSM solutions are suitable blood diluents.

Claims

1. A composition suitable for application to tissue and/or body fluids of a human or other animal subject comprising a pharmaceutically acceptable composition containing about one to twenty weight percent methylsulfonylmethane as an essential active agent, and an amount from about one to twenty weight percent carbamide effective to enhance the activity of the methylsulfonylmethane.

2. A composition as in claim 1 adapted for topical application and containing up to about fifteen weight percent carbamide.

3. A composition as in claim 2 comprising at least about five weight percent carbamide.

4. A composition as in claim 2 comprising:

about 2 to about 10 weight percent methylsulfonylmethane, and about 2 to about 10 weight percent carbamide.

5. A composition as in claim 4 wherein the composition is a viscous liquid of the group including creams, lotions and gels.

6. A composition as in claim 5 wherein the composition is an injectable solution.

7. A composition as in claim 4 comprising methylsulfonylmethane in a gaseous medium.

8. A composition as in claim 1 further comprising up to thirty weight percent DMSO.

21. A method for treating finger and/or toe nails of a human or other animal subject comprising topically administering to the nails of the subject, an amount of a composition of claim 4 to effectively reduce the brittleness of the nails.

22. A method for removing cuticle from the finger and/or toe nails of a human or other animal subject, comprising topically administration to the cuticle, a composition of claim 4 in an amount effective to soften the cuticle so that it can be removed by gentle rubbing.

9. A composition for topical application to the skin of a human or other animal subject comprising an aqueous solution of one to ten weight percent each of methylsulfonylmethane and carbamide in a combined amount such that the composition is capable of eliciting a physiological effect upon application of the composition, the ratio of methylsulfonylmethane to carbamide being such that the extent of the physiological effect is greater than the extent of the effect which results from application of an otherwise identical composition containing only one of said methylsulfonylmethane and carbamide in an amount equal to said combined amount.

10. In a chemical composition containing carbamide, an amount of methylsulfonylmethane effective to retard decomposition of the carbamide.

11. A method for altering the condition of tissue and/or body fluids of a human or other animal subject comprising concurrently topically administering to the subject one to twenty weight percent methylsulfonylmethane and an amount of carbamide in the range of one to twenty weight percent effective to enhance the activity of the methylsulfonylmethane.

12. A method as in claim 11 wherein the carbamide is administered in a composition which includes the methylsulfonylmethane.

13. A method as in claim 11 wherein the carbamide is administered to the subject in a composition containing at least about five weight percent carbamide.

14. A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to enhance moisture retention of the skin.

15. A method as in claim 11 wherein the methane and carbamide are administered to skin of a subject suffering from irritation of the skin in an amount sufficient to relieve discomfort resulting from the irritation.

16. A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to soften the skin.

17. A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to increase the smoothness of the skin.

18. A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to preserve the pliancy of the skin.

19. A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject, prior to shaving the skin with a razor blade, in an amount effective to reduce the drag of the razor during shaving.

20. A method as in claim 11 wherein the methane and carbamide are administered to connective tissue of the subject.

23. A method as in claim 12 wherein the methylsulfonylmethane and carbamide are administered as a pharmaceutically acceptable composition adapted for topical administration and containing up to 15 weight percent of methylsulfonylmethane.

24. A method as in claim 12 wherein the composition administered contains about 1 to about 10 weight percent each of methylsulfonylmethane and carbamide.

25. A method as in claim 12 wherein the composition administered also contains up to 30 weight percent dimethylsulfoxide.