Glycosylated insulin derivatives
First Claim
1. A glycosylated insulin having the formula ##STR24## wherein X and Z are different and are selected from the group consisting of --H and --OH, n is an integer of 2 to 6 and m is an integer of 1 to 3, and wherein each glycosyl group is attached to the insulin by an amide linkage through one or more of the α
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
-amino group of the B-29 lysine moieties of the insulin molecule.
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Accused Products
Abstract
Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)-phenyl-α-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-α-D-gluco- and mannopyranosides and p-(isothiocyanotophenyl)-α-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and shown significant activity in depressing blood sugar levels.
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Citations
5 Claims
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1. A glycosylated insulin having the formula ##STR24## wherein X and Z are different and are selected from the group consisting of --H and --OH, n is an integer of 2 to 6 and m is an integer of 1 to 3, and wherein each glycosyl group is attached to the insulin by an amide linkage through one or more of the α
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
-amino group of the B-29 lysine moieties of the insulin molecule. - View Dependent Claims (2, 3, 4, 5)
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
Specification