Glycosylated insulin derivatives
First Claim
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1. A glycosylated insulin having the formula ##STR20## wherein n is an integer of 2 to 6, m is an integer of 1 to 3 and wherein the glycosyl group is attached to the insulin through one or more of the α
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
-amino group of the B-29 lysine moieties of the insulin molecule.
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Abstract
Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)- phenyl-α-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-α-D-gluco- and mannopyranosides and p-(isothiocyanotophenyl)-α-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and show significant activity in depressing blood sugar levels.
3 Citations
3 Claims
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1. A glycosylated insulin having the formula ##STR20## wherein n is an integer of 2 to 6, m is an integer of 1 to 3 and wherein the glycosyl group is attached to the insulin through one or more of the α
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
-amino group of the B-29 lysine moieties of the insulin molecule. - View Dependent Claims (2, 3)
- -amino groups of the A-1 glycine, B-1 phenylalanine or ε
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Current AssigneeUniversity of Utah (State of Utah)
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Original AssigneeUniversity of Utah (State of Utah)
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InventorsMcRea, James C., Kim, Wan S., Jeong, Seo Y.
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Primary Examiner(s)WADDELL, FREDERICK
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Application NumberUS06/532,915Time in Patent Office336 DaysField of Search424/178, 260/112.7US Class Current530/303CPC Class CodesA61K 38/00 Medicinal preparations cont...C07H 15/203 Monocyclic carbocyclic ring...
