Precision medication dispensing system and method

• US 4,486,190 A
• Filed: 12/27/1982
• Issued: 12/04/1984
• Est. Priority Date: 12/27/1982
• Status: Expired due to Fees

• Current Assignee: Eaton Corp. (Wisconsin) (Eaton Corporation PLC.)
• Original Assignee: Consolidated Controls Corporation
• Inventors: Reinicke, Robert H.
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/453,594
• Time in Patent Office: 708 Days
• Field of Search: 604/65-67, 604/118, 604/891, 604/151-153, 3/1.7, 128/DIG. 13
• US Class Current: 604/67
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G05D 7/0676 by action on flow sources G05D7/0688, G05D7/0694 take precedence

Abstract

The implantable device includes a medication reservoir, a pulsatile pump and an absolute pressure transducer. The pumping pressure wave developed in the pumping chamber is measured by the absolute pressure transducer whose output is used to adjust the pulsing rate of the solenoid operated pump so that the programmed time averaged rate of infusion of medication into the body is precisely maintained throughout all operating temperature and pressure conditions.

Claims

1. In a system for infusing medication into a body, the combination of, a medication reservoir, a flow restriction means having an outlet for infusing medication into the body, metering means connected betwen said reservoir and the inlet of said flow restriction means for periodically supplying a small portion of the medication in said reservoir to the inlet of said flow restriction means during successive spaced apart dispensing periods, means for measuring the exact amount of medication supplied to said flow restriction outlet during each dispensing period, said measuring means including a pressure transducer for developing a signal corresponding to the pressure transient developed at said inlet of said flow restriction means during each of said dispensing periods, and means responsive to said measuring means for varying the time between successive dispensing periods so as to maintain the rate of infusion of medication into the body at a desired value.

2. The combination of claim 1, wherein said flow restriction means allows the pressure at the inlet thereof to become equal to the pressure at said outlet in the intervals between dispensing periods, and means for periodically sampling the output of said pressure transducer during one of said dispensing periods and subtracting from each sample the output of said pressure transducer during said intervals to obtain successive samples representing the differential pressure across said flow restriction means during said one dispensing period.

3. The combination of claim 2, wherein the output of said pressure transducer is subject to drift and said differential pressure samples are compensated for such drift by subtracting the output of the pressure transducer during the interval between dispensing periods from the output of the pressure transducer during one of the dispensing periods.

4. The combination of claim 2, which includes means for converting said differential pressure samples into signals representing the corresponding flow of medication through said flow restriction means, and means responsive to said signals for developing an output signal representing the total volume of medication supplied to said outlet during each of said dispensing periods.

5. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, a flow restrictor positoned between said pumping chamber and said outlet, said flow restrictor allowing the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element, and a pressure transducer for measuring the absolute pressure within said pumping chamber and developing an electrical signal which varies in accordance with the instantaneous pressure within said pumping chamber, whereby said electrical signal includes a base line portion proportional to the pressure at said outlet during said intervals and a pumping pressure transient portion which varies in accordance with variations in the pressure within said chamber during pumping strokes of said pump element, and means controlled by said electrical signal for varying the rate at which said pump is actuated so as to maintain a predetermined average rate of flow of medication to said outlet.

6. The combination of claim 5, which includes means for storing a value proportional to said base line portion of said electrical signal, and means for periodically subtracting said base line value from the instantaneous value of said electrical signal during said pumping pressure transient portion of said electrical signal to obtain successive values of the differential pressure across said flow restrictor during said pumping pressure transient, and means controlled by said successive differential pressure values for calculating the actual flow of medication to said outlet during said pumping pressure transient.

7. The combination of claim 6, which includes means for developing a reference signal corresponding to a desired flow of medication to said outlet, and means jointly responsive to said successive differential pressure values and said reference signal for controlling the rate at which said pump element is actuated so as to maintain the flow of medication to said outlet at said desired value.

8. The combination of claim 7, which includes means for converting said successive differential pressure values into corresponding rates of flow through said restrictor, and means for integrating said successive converted flow rates to obtain an output corresponding to the total volume of medication supplied to said outlet during one stroke of said pump element.

9. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, a pressure transducer for developing an electrical signal corresponding to the pressure transient developed within said pumping chamber during one stroke of said pump element, means for generating successive signals corresponding to the flow of medication to said outlet during successive portions of said pressure transient, means responsive to said successive signals for developing an output signal corresponding to the total volume of medication supplied to said outlet during said one stroke of said pump element, and means controlled at least in part by said output signal by varying the rate at which said pump element is stroked to maintain the volume of medication supplied to said outlet per unit of time at a predetermined value.

10. The combination of claim 9, which includes means for integrating said successive signals to obtain said output signal.

11. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, a flow restrictor connected between said pumping chamber and said outlet, said flow restrictor allowing the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element, means for measuring the precise volume of medication pumped to said outlet on each stroke of said pump element, and means controlled at least in part by said measuring means for varying the rate at which said pump element is stroked to maintain the volume of medication supplied to said outlet per unit of time at a predetermined value.

12. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, a flow restrictor connected between said pumping chamber and said outlet, said flow restrictor allowing the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element, a pressure transducer for developing an electrical signal corresponding to the pressure transient developed within said pumping chamber during one stroke of said pump element, means for generating a series of signals corresponding to the differential pressure across said flow restrictor at different points along said pressure transient, means responsive to each of said series of differential pressure signals for developing a signal representing the corresponding flow of medication through said flow restrictor, means responsive to said series of flow signals for developing an output signal representing the total volume of medication supplied to said outlet during said one stroke of said pump element, and means controlled at least in part by said output signal for varying the rate at which said pump element is stroked to maintain the volume of medication supplied to said outlet per unit of time at a predetermined value.

13. The combination of claim 12, wherein said series of flow signals are digital signals, and accumulator means for summing said series of flow signals to provide said output signal.

15. The combination of claim 12, which includes means for actuating said pump element at a variable rate, means for generating a reference signal corresponding to a desired flow of medication to said outlet, means for comparing said reference signal with said output signal to develop an error signal corresponding to the difference therebetween, and means controlled by said error signal for varying the rae of actuation of said pump element by said actuating means to maintain said desired flow of medication to said outlet.

14. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, a flow restrictor connected between said pumping chamber and said outlet, said flow restrictor allowing the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element, a pressure transducer for developing an electrical signal corresponding to the pressure transient developed within said pumping chamber during one stroke of said pump element, means responsive to said electrical signal for generating a differential pressure signal which varies in accordance with the differential pressure across said flow restrictor during said pressure transient, means for converting said different pressure signal into a corresponding flow rate signal whose amplitude varies in accordance with variations in flow through said flow restrictor during said pressure transient, means for integrating said flow rate signal, thereby to provide an output signal representing the total volume of medication supplied to said outlet during said one stroke of said pump element, and means controlled at least in part by said output signal for varying the rate at which said pump element is stroked to maintain the volume of medication supplied to said outlet per unit of time at a predetermined value.

16. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, means for actuating said pump element at a variable rate, means for generating a reference signal corresponding to a desired flow of medication to said outlet, means for developing an output signal representing the precise volume of medication pumped to said outlet on each stroke of said pump element, said means for developing an output signal including a pressure transducer for developing an electrical signal corresponding to the pumping pressure transient developed within said pumping chamber during one stroke of said pump element, means for comparing said reference signal and said output signal to develop an error signal corresponding to the difference therebetween, and means controlled by said error signal for varying the rate of actuation of said pump element by said actuating means to maintain said desired flow of medication to said outlet.

17. The combination of claim 16, which includes pressure transducer calibration means for modifying said electrical signal to correct for non-linearity in the output of said pressure transducer.

18. The combination of claim 16, which includes A/D converter means for developing a digital signal corresponding to the output of said pressure transducer.

19. The combination of claim 18, which includes transducer calibration means connected to the output of said A/D converter means to correct for non-linearity in the output of said pressure transducer.

20. The combination of claim 16, which includes a flow restrictor connected between said pumping chamber and said outlet, said flow restrictor allowing the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element.

21. The combination of claim 20, which includes means for storing a value corresponding to the pressure in said pumping chamber during said intervals.

22. The combination of claim 21, which includes means for periodically subtracting said stored value from the output of said pressure transducer during said pressure transient to obtain a succession of signals representing the differential pressure across said flow restrictor at different times during said pressure transient.

23. The combination of claim 22, which includes means for converting said succession of signals into signals representing the flow rate through said restrictor corresponding to each of said differential pressure signals.

24. The combination of claim 23, which includes means for combining said flow rate signals to provide said output signal.

25. The combination of claim 21, which includes means for periodically sampling said pressure transient to provide successive values corresponding to the amplitude of said pressure transient relative to said stored value at different times during said pressure transient.

26. The combination of claim 25, which includes means controlled by said successive values for developing said output signal.

27. In a system for infusing medication into a body, the combination of, a medication reservoir, a medication outlet for infusing medication into the body, positive displacement pump means connected between said reservoir and said outlet and including a pumping chamber and a pump element movable through a predetermined stroke within said chamber to force medication from said reservoir into said medication outlet, means for actuating said pump element at a variable rate, means for generating a reference signal corresponding to a desired flow of medication to said outlet, a flow restrictor connected between said pumping chamber and said outlet, said flow restrictor permitting the pressure within said pumping chamber to become equal to the pressure at said outlet in the intervals between strokes of said pump element, means for developing a first signal corresponding to the pressure in said chamber during said intervals, means for developing a second signal which varies in accordance with variations in the pressure within said chamber during strokes of said pump element, means responsive to said first and second signals for developing a control signal means for comparing said reference signal and said control signal to develop an error signal corresponding to the difference therebetween, and means controlled by said error signal for varying the rate of actuation of said pump element by said actuating means to maintain said desired flow of medication to said outlet.