×

Cyclic hexapeptide somatostatin analogs

  • US 4,486,415 A
  • Filed: 08/15/1983
  • Issued: 12/04/1984
  • Est. Priority Date: 08/15/1983
  • Status: Expired due to Fees
First Claim
Patent Images

1. A compound having the formula:

  • ##STR24## wherein X is (CH2)n wherein n is 0, 1 or 2 or sulfur;

    Y is (CH2)m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain;

    R1 and R2 are independently lower alkyl, benzyl, substituted benzyl wherein the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and

    loweralkyl substituted with hydroxy, carboxy, amino, guanidino, or a 5- or 6-membered heterocyclic ring;

    R3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy or halogen;

    R4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted hydroxy benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro;

    R5 is loweralkyl, benzyl, or substituted benzyl wherein the substituent is loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro; and

    R6 and R7 are independently hydrogen or straight chain loweralkyl provided at least one of R6 and R7 is loweralkyl.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×