Cephem compounds

• US 4,487,768 A
• Filed: 12/22/1982
• Issued: 12/11/1984
• Est. Priority Date: 12/22/1982
• Status: Expired due to Fees

• Current Assignee: Fujisawa Pharmaceutical Co., Ltd. (Astellas Pharma Incorporated)
• Original Assignee: Fujisawa Pharmaceutical Co., Ltd. (Astellas Pharma Incorporated)
• Inventors: Takasugi, Hisashi, Takaya, Takao, Masugi, Takashi, Miyai, Kenzi
• Primary Examiner(s): Coughlan, Jr., Paul M.
• Application Number:
  US06/452,301
• Time in Patent Office: 720 Days
• Field of Search: 424/246, 544/22
• US Class Current: 514/208
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07D 501/46 with the 7-amino radical acylated by carboxylic acids containing hetero rings

Abstract

The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R¹ is amino or protected amino,

R² is carboxy(lower)alkyl or protected carboxy(lower)alkyl, and

R³ is carboxy or protected carboxy,

and a pharmaceutically acceptable salt thereof.

Claims

1. A compound of the formula:

##STR6## wherein R¹ is amino or protected amino,

R² is carboxy(lower)alkyl or protected carboxy(lower)alkyl, and

R³ is carboxy or protected carboxy,

and a pharmaceutically acceptable salt thereof.

2. A compound of claim 1, which is

7-[2-carboxymethoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetamido]-3-azidomethyl-3-cephem-4-carboxylic acid (syn isomer).

3. An antibacterial composition comprising an effective amount of a compound of claim 1 in association with a pharmaceutically acceptable substantially non-toxic carrier or excipient.