Topical agent for transcutaneous measurement of partial pressure of oxygen

• US 4,488,557 A
• Filed: 03/02/1984
• Issued: 12/18/1984
• Est. Priority Date: 03/02/1984
• Status: Expired due to Fees

• Current Assignee: Rolf R. Engel
• Original Assignee: Rolf R. Engel
• Inventors: Engel, Rolf R.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Dalgewicz, III, Edward J.
• Application Number:
  US06/585,774
• Time in Patent Office: 291 Days
• Field of Search: 128/635, 128/639-641, 604/336, 604/892, 204/403, 204/414, 204/431, 204/803, 424/275, 427/2
• US Class Current: 600/357
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1477 non-invasive
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61K 31/38 having sulfur as a ring hetero atom

Abstract

The invention relates to a method for treating skin for assisting transcutaneous measurement of arterial partial pressure of oxygen. The method involves applying topically 2-thenoyltrifluoroacetone to the area of skin over which the partial pressure of oxygen is to be measured.

Claims

1. A method for transcutaneous measurement of arterial partial pressure of oxygen comprising:

applying topically 2-thenoyltrifluoroacetone to an area of skin over which the partial pressure of oxygen is to be measured;

placing a sensor unit over the area of skin to which the 2-thenoyltrifluoroacetone has been applied and sealing the area of skin from the ambient atmosphere;

raising the temperature of the area of skin by heat emanating from the sensor unit; and

measuring with the sensor unit the transcutaneous partial pressure of oxygen over the area of skin.

2. The method of claim 1 wherein the 2-thenoyltrifluoroacetone is in crystalline form and is applied directly to the area of skin over which the partial pressure of oxygen is to be measured.

3. The method of claim 2 wherein the amount of 2-thenoyltrifluoroacetone crystals is about 5 mg or less.

4. The method of claim 1 wherein the 2-thenoyltrifluoroacetone is embodied in a gelatinous or solid matrix delivery medium.

5. The method of claim 1 wherein the 2-thenoyltrifluoroacetone is dissolved or suspended in a liquid medium prior to topical application.

6. The method of claim 5 wherein the amount of 2-thenoyltrifluoroacetone in the liquid medium is in the range of about 2% to about 3% by weight.

7. The method of claim 6 wherein the amount of 2-thenoyltrifluoroacetone in the liquid medium is about 2% by weight.

8. The method of claim 5 wherein the liquid medium further comprises contact gel for use between the area of skin and a membrane, the membrane separating sensor electrodes from the skin.

9. The method of claim 8 wherein the contact gel comprises water and glycerol.

10. The method of claim 9 wherein the liquid medium further comprises propylene glycol.