Methods of treating disorders of an eye with liquid perfluorocarbons

• US 4,490,351 A
• Filed: 03/15/1982
• Issued: 12/25/1984
• Est. Priority Date: 03/15/1982
• Status: Expired due to Term

• Current Assignee: Vitrophage, Inc.
• Original Assignee: Children's Hospital & Medical Center
• Inventors: Clark, Leland C. Jr.
• Primary Examiner(s): WADDELL, FREDERICK
• Application Number:
  US06/358,055
• Time in Patent Office: 1,016 Days
• Field of Search: 424/5, 424/352
• US Class Current: 424/9.4
• CPC Class Codes: A61K 31/025 carbocyclic
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/00 Materials for grafts or prostheses or for coating grafts or prostheses dental prostheses A61C13/00; shape or structure of prostheses A61F2/00; use of preparations for artificial teeth A61K6/80; artificial kidneys A61M1/14

Abstract

Liquid perfluorocarbons and substituted derivatives thereof are used as fluid substitutes for the vitreous or the aqueous of the eye. These liquids are also used to transparentize the cornea or lens when either becomes opacifed due to degeneration or cataract formation. Methods involving the use of these liquids during retinal surgery or diagnostic procedures of the eye are also disclosed.

Claims

1. A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a liquid comprising a liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.

2. The method of claim 1 wherein said liquid is introduced into the vitreous of the eye.

3. The method of claim 2 wherein said vitreous is substantially replaced with said liquid.

4. The method of claim 2 wherein the introduction of said liquid into said vitreous and the withdrawal of vitreous from said eye is conducted at the same time.

5. The method of claim 1 wherein said liquid is introduced into the aqueous of the eye.

6. The method of claim 5 wherein said aqueous is substantially replaced with said liquid.

7. The method of claim 1 wherein said liquid is introduced into the cornea.

8. The method of claim 7 wherein said liquid is introduced in a sufficient amount to form a substantially transparent window in said cornea.

9. The method of claim 1 wherein said liquid is introduced into the lens.

10. The method of claim 9 wherein said liquid is introduced in a sufficient amount to form a substantially transparent window in said lens.

11. The method of claim 1 wherein said perfluorocarbon or substituted derivative thereof is in a physical state selected from the group consisting of neat liquid, emulsion, gel, solution and suspension.

12. The method of claim 1 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.

13. The method of claim 12 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.

14. The method of claim 1 wherein said liquid perfluorocarbon is radiopaque.

15. The method of claim 14 wherein said perfluorocarbon is selected from the group consisting of a brominated perfluorocarbon and an iodinated perfluorocarbon.

16. The method of claim 14 wherein said liquid perfluorocarbon is perfluorooctylbromide.

20. The method of claim 1 comprising introducing a radiopaque liquid perfluorocarbon or substituted derivative thereof in an amount effective to detect radiopacity and x-raying said intraocular structural disorder.

21. The method of claim 20 wherein said liquid perfluorocarbon is selected from the group consisting of a brominated perfluorocarbon and an iodinated perfluorocarbon.

22. The method of claim 20 wherein said liquid perfluorocarbon is perfluorooctylbromide.

17. A method of repairing a retinal disorder of an eye of an animal comprising introducing into the vitreous of said eye a liquid comprising a liquid perfluorocarbon or substituted derivative thereof, locating said animal in a position to provide means for said liquid to maintain the retina against the choroid of said eye to repair said retina, and maintaining said animal in said position for a time to effect said repair.

18. The method of claim 17 wherein said retinal disorder is either a detached or torn retina.

19. The method of claim 17 wherein said liquid is removed from said vitreous after said repair.

23. A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a substantially transparent liquid perfluorocarbon or substituted derivative thereof in an amount effective to treat said intraocular structural disorder.

24. The method of claim 23 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.

25. The method of claim 24 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnapthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.

26. A method of treating an intraocular structural disorder of an eye comprising introducing a liquid comprising a liquid perfluorocarbon or substituted derivative thereof into a structure of an eye under treatment selected from the group consisting of anterior chamber, a posterior chamber, cornea, lens and vitreous body in an amount effective to treat said disorder.

27. A method of reparing a clouded cornea of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said cornea in an amount effective to provide a substantially transparent window therein.

28. The method of claim 27 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.

29. A method of reparing a clouded lens of an eye comprising introducing a substantially transparent liquid comprising a liquid perfluorocarbon or substituted derivative thereof into said lens in an amount effective to provide a substantially transparent window therein.

30. The method of claim 29 wherein said liquid perfluorocarbon is a perfluorocyclocarbon.