Low toxicity radiation sensitizer
First Claim
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1. Bis(5-aminofluorescein)dichloroplatinum(II) of the formula:
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Abstract
Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.
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1 Claim
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1. Bis(5-aminofluorescein)dichloroplatinum(II) of the formula:
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Specification
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Current AssigneeUniversity of Northern California Foundation
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Original AssigneeUniversity of Northern California Foundation
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InventorsChang, James C., Bergquist, Barton L.
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Primary Examiner(s)Milestone, Norma S.
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Application NumberUS06/440,840Time in Patent Office774 DaysField of Search549/212US Class Current549/212CPC Class CodesC07F 15/0093 without a metal-carbon linkage
