Method of stimulating satiety in mammals
First Claim
1. A method of stimulating satiety in mammals by administering to them a therapeutically effective amount of a trypsin inhibitor which stimulates the release of cholecystokinin.
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Abstract
This disclosure relates to a method of eliciting satiety (psycho phenomenetic sense of being filled) in mammals through the administration of an effective amount of a trypsin inhibitor and is based on the postulate that the enzyme trypsin, normally secreted by the pancreas, constitutes a negative feedback signal for cholecystokinin secretion which in turn comprises a putative satiety signal; thus, the effect of the trypsin inhibitor is to increase the concentration of cholecystokinin secretion advancing the sensation of satiety resulting in a consequent decrease in food intake and, over time, body weight.
24 Citations
2 Claims
- 1. A method of stimulating satiety in mammals by administering to them a therapeutically effective amount of a trypsin inhibitor which stimulates the release of cholecystokinin.
Specification
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- Resources
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Current AssigneeSteven R. Peikin
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Original AssigneeSteven R. Peikin
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InventorsPeikin, Steven R.
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Primary Examiner(s)Robinson, Douglas W.
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Application NumberUS06/516,937Time in Patent Office526 DaysField of Search424/309, 424/177, 424/300US Class Current514/4.8CPC Class CodesA61K 38/005 Enzyme inhibitors protease ...
