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Reporter compounds

  • US 4,496,722 A
  • Filed: 05/01/1981
  • Issued: 01/29/1985
  • Est. Priority Date: 05/01/1981
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula ##STR93## wherein Rp1 is a group which includes a reporter group chosen from the group consisting of a fluorophore or a chromophore and which is capable of being bonded to the boron atom of a boronic acid,each of X and Y, independently, is O, NR6, or ##STR94## wherein each R6 and R7, independently, is H, --CH2 COO-, --CH2 CH2 SO3-, or --CH2 CH2 CH2 SO3-, provided that one of x or y is O and provided that at least one of R6 or R7 is H;

  • ##STR95## forms the heterocyclic ring structure ##STR96## Cg1 is a carrier group which includes a solubilizing group which is ionized in water, and r is a receptor group which, with X and Y, forms complexes with boronic acids,said r-Cg1 being ##STR97## so that said compound has the formula ##STR98## wherein each R2 -R5, independently is selected from H, or one of --CH3, - CH2 --COO-, and - CH2 SO3-,provided that the compound contains at least one solubilizing group, said solubilizing group being a sulfonate group, a carboxylate group, a quaternary ammonium group as indicated above a guanidinium group, or a phosphate group.

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