Reporter compounds
First Claim
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1. A compound of the formula ##STR93## wherein Rp1 is a group which includes a reporter group chosen from the group consisting of a fluorophore or a chromophore and which is capable of being bonded to the boron atom of a boronic acid,each of X and Y, independently, is O, NR6, or ##STR94## wherein each R6 and R7, independently, is H, --CH2 COO-, --CH2 CH2 SO3-, or --CH2 CH2 CH2 SO3-, provided that one of x or y is O and provided that at least one of R6 or R7 is H;
- ##STR95## forms the heterocyclic ring structure ##STR96## Cg1 is a carrier group which includes a solubilizing group which is ionized in water, and r is a receptor group which, with X and Y, forms complexes with boronic acids,said r-Cg1 being ##STR97## so that said compound has the formula ##STR98## wherein each R2 -R5, independently is selected from H, or one of --CH3, - CH2 --COO-, and - CH2 SO3-,provided that the compound contains at least one solubilizing group, said solubilizing group being a sulfonate group, a carboxylate group, a quaternary ammonium group as indicated above a guanidinium group, or a phosphate group.
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Abstract
Compounds and methods featuring, in one aspect, compositions containing an organic boronic acid and one or more reporter groups.
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Citations
4 Claims
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1. A compound of the formula ##STR93## wherein Rp1 is a group which includes a reporter group chosen from the group consisting of a fluorophore or a chromophore and which is capable of being bonded to the boron atom of a boronic acid,
each of X and Y, independently, is O, NR6, or ##STR94## wherein each R6 and R7, independently, is H, --CH2 COO-, --CH2 CH2 SO3-, or --CH2 CH2 CH2 SO3-, provided that one of x or y is O and provided that at least one of R6 or R7 is H; - ##STR95## forms the heterocyclic ring structure ##STR96## Cg1 is a carrier group which includes a solubilizing group which is ionized in water, and r is a receptor group which, with X and Y, forms complexes with boronic acids,
said r-Cg1 being ##STR97## so that said compound has the formula ##STR98## wherein each R2 -R5, independently is selected from H, or one of --CH3, - CH2 --COO-, and - CH2 SO3-, provided that the compound contains at least one solubilizing group, said solubilizing group being a sulfonate group, a carboxylate group, a quaternary ammonium group as indicated above a guanidinium group, or a phosphate group.
- ##STR95## forms the heterocyclic ring structure ##STR96## Cg1 is a carrier group which includes a solubilizing group which is ionized in water, and r is a receptor group which, with X and Y, forms complexes with boronic acids,
- 2. A compound of the formula ##STR99## wherein RP1 is selected from ##STR100## and the ##STR101## portion of said compound is selected from ##STR102##
Specification
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Current AssigneeChildren's Medical Center Corporation
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Original AssigneeChildren's Medical Center Corporation
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InventorsGallop, Paul M., Paz, Mercedes
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Primary Examiner(s)Coughlan, Jr., Paul M.
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Assistant Examiner(s)SPRINGER, DAVID B
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Application NumberUS06/259,705Time in Patent Office1,369 DaysField of Search548/110, 544/69US Class Current544/69CPC Class CodesA61K 47/545 Heterocyclic compounds A61K...C07F 17/02 of metals of Groups 8, 9 or...C07F 5/025 Boronic and borinic acid co...C12Q 1/28 involving peroxidaseG01N 33/532 Production of labelled immu...
