Gentisic acid salts as radiographic scanning agent stabilizers

• US 4,497,744 A
• Filed: 11/03/1980
• Issued: 02/05/1985
• Est. Priority Date: 03/31/1978
• Status: Expired due to Term

• Current Assignee: Mallinckrodt Medical Inc. (Mallinckrodt plc)
• Original Assignee: Mallinckrodt Incorporated (Mallinckrodt plc)
• Inventors: Fawzi, Mahdi B.
• Primary Examiner(s): SNEED, HELEN
• Application Number:
  US06/202,962
• Time in Patent Office: 1,555 Days
• Field of Search: 260/429.7, 260/439 R, 260/438.5 R
• US Class Current: 556/61
• CPC Class Codes: A61K 2123/00 Preparations for testing in vivo
• CPC Class Codes: A61K 51/0489 Phosphates or phosphonates, e.g. bone-seeking phosphonates; phospholipids: A61K51/0408; nucleotides or nucleic acids: A61K51/0491
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234

Abstract

Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise gentisic acid or a pharmaceutically-acceptable salt or ester thereof in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (^99m TcO₄^-) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.

Claims

1. The water-soluble compound stannous gentisate.

2. The water-soluble compound chromous gentisate.