Control circuit for a blood fractionation apparatus

• US 4,501,531 A
• Filed: 12/05/1983
• Issued: 02/26/1985
• Est. Priority Date: 12/15/1981
• Status: Expired due to Fees

• Current Assignee: Baxter Travenol Laboratories Incorporated
• Original Assignee: Baxter Travenol Laboratories Incorporated
• Inventors: Bilstad, Arnold C., Foley, John T.
• Primary Examiner(s): Look, Edward K.
• Application Number:
  US06/557,818
• Time in Patent Office: 449 Days
• Field of Search: 604/50, 604/51, 604/4-6, 604/122, 604/123, 604/65-67, 604/131, 604/151, 604/245-247, 128/DIG. 12, 128/DIG. 13, 417/12, 417/63, 417/44, 417/45, 340/691, 340/502
• US Class Current: 417/63
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3672 Means preventing coagulation

Abstract

An apparatus for the continuous flow fractionation of whole blood incorporates motor driven whole blood, anti-coagulant and replacement pumps, negative and positive pressure monitors, and a dual bubble detector which function in conjunction with a disposable single-use flow system and a hollow fiber filter to separate and collect plasma from whole blood. Operation of the pump motors, pressure monitors and bubble detector is controlled by a control circuit within the apparatus to provide one of several operator-selected operating modes, including run, prime and reinfuse modes. The control circuit provides an alarm which can be cancelled by the operator when certain system parameters fall outside of normal operating limits, and interrupts operation of the pumps when the parameters exceed maximum limits. A failsafe circuit independent of the control circuits interrupts power to the pump motors in the event the motors do not stop upon detection of a bubble or fluid absence in the flow system.

Claims

1. In a blood fractionation apparatus operable in conjunction with a disposable flow system for separating and collecting a blood fraction from whole blood, and including at least one motor-driven pump for conveying blood through the flow system, and a monitoring device providing an alarm output response to an abnormal condition in the system, a control circuit comprising, in combination:

a flip-flop responsive to a momentary alarm output from said monitoring device for producing a first alarm control signal;

a latch register responsive to the occurrence of said control signal for producing a second alarm control signal upon application of a latch signal;

aural alarm means;

visual alarm means;

alarm control circuit means responsive to said first alarm control signal for activating said aural and visual alarm means, and responsive to said second alarm control signal for inhibiting only said aural alarm means; and

user-actuated switch means for applying a latch control signal to said latch register to cancel said aural alarm without cancelling said visual alarm.

2. A blood fractionation apparatus as defined in claim 1 wherein said flip-flop is an RS type flip-flop.

3. A blood fractionation apparatus as defined in claim 1 wherein said alarm control circuit means intermittently actuate said aural and visual alarm means prior to actuation of said latch register.

4. A blood fractionation apparatus as defined in claim 1 wherein said alarm control circuit means include a first AND gate having one input connected to the output of said flip-flop, and another input connected to the output of said latch register, and an output connected to said aural alarm means.

5. A blood fractionation apparatus as defined in claim 4 wherein said alarm control circuit includes a second AND gate having one input connected to the output of said flip-flop, another input connected to the output of said first AND gate, and an output connected to said visual alarm.

6. A blood fractionation apparatus as defined in claim 5 including a source of intermittent control signals, and wherein said first AND gate includes an input coupled to said source of intermittent control signals whereby said aural and visual alarms are intermittently operated in the presence of said first alarm control signal and in the absence of said second alarm control signal.

7. In a blood fractionation apparatus operable in conjunction with a disposable flow system for separating and collecting a blood fraction from whole blood, and including at least one motor-driven pump for conveying blood through the flow system, and a monitoring device providing an alarm output in response to an abnormal condition in the system, a control circuit comprising, in combination:

a flip-flop responsive to a momentary alarm output from said monitoring device for producing a first alarm control signal;

a latch register responsive to the occurrence of said first alarm control signal for producing a second alarm control signal upon application of a latch control signal;

aural alarm means;

visual alarm means;

alarm control means including a first AND gate having inputs connected to the outputs of said flip-flop and said latch register, and an output connected to said aural alarm, and a second AND gate having inputs connected to the outputs of said flip-flop and said first AND gate, and an output connected to said visual alarm, for activating said aural and visual alarm means in response to said first alarm control signal, and only said visual alarm control signal in the presence of said second alarm control signal; and

user-actuated switch means for applying a latch control signal to said latch register to cancel said aural alarm without cancelling said visual alarm.

8. A blood fractionation apparatus as defined in claim 7 wherein said first AND gate has a third input, and wherein said apparatus includes a pulse source for applying pulses to said first AND gate to intermittently sound said alarm.

9. A blood fractionation apparatus as defined in claim 7 wherein said second alarm control signal is of opposite binary gender to said first alarm control signal.