Masking of liposomes from RES recognition

• US 4,501,728 A
• Filed: 01/06/1983
• Issued: 02/26/1985
• Est. Priority Date: 01/06/1983
• Status: Expired due to Term

• Current Assignee: Calfee, Halter & Griswold LLP
• Original Assignee: Technology Unlimited Incorporated
• Inventors: Geho, W. Blair, Lau, John R.
• Primary Examiner(s): Lovering, Richard D.
• Assistant Examiner(s): SCALZO, CATHERINE KILBY
• Application Number:
  US06/456,269
• Time in Patent Office: 782 Days
• Field of Search: 424/38, 424/31, 424/9, 424/19, 428/402.2, 436/829, 264/4.6
• US Class Current: 424/450
• CPC Class Codes: A61K 49/1812 liposomes, polymersomes, e.g. immunoliposomes
• CPC Class Codes: A61K 9/1271 Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers liposome as conjugate A61K47/6911
• CPC Class Codes: Y10S 436/829 Liposomes, e.g. encapsulation
• CPC Class Codes: Y10T 428/2984 Microcapsule with fluid core [includes liposome]

Abstract

A biochemical membrane covered with sialic residues thereby provides a coating that masks the surface membrane from recognition and removal by the scavenging RES cells of the body.

Claims

1. A delivery system consisting essentially of a biochemical membrane containing a drug, hormone, diagnostic or nutritional material covered with sialic acid residues such that the membrane is shielded from the RES thereby providing a coating that masks the surface membrane from recognition by the scavenging cells of the body.

2. The surface of the membrane in claim 1 which has an amphiphilic coating including N-acetylneuraminic acid.

3. A liposome having a core with at least one entrapped drug, hormone, diagnostic or nutritional material and the surface thereof masked from recognition by the reticuloendothelial system of the living body by having embedded in said surface the lipophilic portion of an amphiphilic coating which includes N-acetylneuraminic acid, the hydrophilic portion extending therefrom and substantially coating the surface.

4. The method of making a liposome carrier of drug, hormone, diagnostic or nutritional material masked from recognition by the scavenging cells of a living animal comprising the provision of an amphiphilic coating which includes N-acetylneuraminic acid and incorporating such coating into the manufacture of a liposome by known techniques.