Injection system

• US 4,502,488 A
• Filed: 01/13/1983
• Issued: 03/05/1985
• Est. Priority Date: 01/13/1983
• Status: Expired due to Fees

• Current Assignee: Fisher Scientific Co. (Thermo Fisher Scientific Incorporated)
• Original Assignee: Allied Corp. (Honeywell International Inc.)
• Inventors: Oliver, William R., Silverman, Neil D., Degironimo, Bruno, Rideout, Eugene C.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/457,755
• Time in Patent Office: 782 Days
• Field of Search: 128/691-692, 128/713, 128/663, 604/52-53, 604/246, 604/280, 604/283-284, 73/204, 137/596.17-596.18
• US Class Current: 600/505
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An interactive injection system for use with a catheter of the type adapted for insertion into a patient'"'"'s vascular system for thermodilution measurements and the like includes a chamber for storing liquid injectate, means for connecting the chamber to the catheter lumen, and a drive for operating on the chamber to flow liquid injectate from the chamber into the lumen for discharge as a bolus from the lumen into the vascular system of a patient. In preferred embodiments, a temperature sensing probe is connected between the injection chamber and the catheter for monitoring the temperature of injectate as it is introduced into the catheter. Cooperating controller apparatus includes means for operating the drive, operator controlled inputs for selecting injectate rate and volume parameters, another operator controlled input for enabling the injector drive, an input from a sensor adapted to be located in the patient'"'"'s vascular system downstream from the proximal port and operative during an injection cycle in response to a sensed deviation of output (e.g., out of specification for terminating the injection sequence, and a processor for utilizing (e.g., integrating) the sensor output to generate a cardiac output value or similar data.

Claims

1. An interactive injection system comprising

a catheter of the type adapted for insertion into the vascular system of a patient for thermodilution measurements or the like, said catheter having a proximal end, a distal end, a lumen that extends from said proximal end to said distal end, an external connector at said proximal end, a port adjacent said distal end of said catheter, and a thermal sensor located between said port and said distal end, said sensor providing signals as a function of temperature,

bolus injection apparatus including a chamber for storing liquid injectate, said chamber having an outlet port, means for connecting said chamber outlet port to said lumen through said external connector, and

drive means including a stepper motor for decreasing the effective volume of said chamber at a predetermined rate to discharge a predetermined quantity of liquid injectate from said chamber for injection through said lumen and discharge as a bolus from said port into the vascular system of the patient, said drive means including pressure responsive means for stalling said stepper motor to interrupt the decrease in volume of said chamber in response to a predetermined resistance to flow of injectate from said chamber, and

controller apparatus including

processor means including a pulse distributor for applying stepping pulses to said motor, means to vary the distribution of said stepping pulses to change the rate at which injectate is discharged from said chamber,

first operator controlled input means for selecting the quantity of injectate to be discharged from said chamber,

second operator controlled input means for applying pulses from said pulse distributor to said stepper motor for actuating said stepper motor to decrease the effective volume of said chamber at a predetermined rate to discharge said predetermined quantity of liquid injectate from said chamber for injection into the vascular system of the patient through said lumen,

means responsive to signals from said sensor for generating output data as a function of sensed changes in response to injection of said liquid bolus through said catheter lumen into said vascular system, and

output means for presenting output data generated by said processor means.

2. The system of claim 1 and further including third operator controlled input means for drawing said predetermined quantity of injectate into said chamber from an external reservoir.

3. The system of claim 1 wherein said chamber includes a cylinder and a piston disposed in said cylinder for axial movement therein, and said drive means is coupled to said piston, said drive means moving said piston to decrease the volume of said chamber.

4. The system of claim 3 wherein said drive means stalls in response to a sensed resistance at the outlet port of said chamber of about one hundred pounds per square inch to interrupt discharge of injectate from said chamber.

5. The system of claim 1 wherein said chamber has a transparent portion such that the quantity and quality of injectate therein may be observed by the operator.

6. The system of claim 5 wherein said stepper motor is housed in a compartment that is sealed from said chamber and is electrically isolated from said chamber so that the electrical leakage current to the patient does not exceed ten microamperes.

7. The system of claim 1 and further including fault sensitive means responsive to said sensor for interrupting discharge of injectate from said chamber in response to a sensed sensor defect.

8. An interactive injection system comprising

a catheter of the type adapted for insertion into the right ventricle of a patient'"'"'s heart by way of the vena cava for thermodilution measurements and the like, said catheter having a proximal end, a distal end, a lumen that extends from said proximal end to said distal end, an external connector at said proximal end, a port adjacent said distal end of said catheter, and a thermal sensor located between said port and said distal end for providing signals as a function of temperature,

bolus injection apparatus including a chamber for storing liquid injectate, said chamber having an outlet port, means for connecting said chamber outlet port to said lumen through said external connector, and drive means including a stepper motor for decreasing the effective volume of said chamber at a predetermined rate to discharge a predetermined quantity of liquid injectate from said chamber for injection through said lumen and discharge as a bolus from said port into the vascular system of a patient, said stepper motor stalling when the catheter resistance to discharge of said liquid from said chamber exceeds about one hundred pounds per square inch to interrupt flow of injectate from said chamber into said catheter,

controller apparatus including pulse distributor means for applying pulses to said stepper motor for operating said drive means, processor means responsive to signls from said sensor for controlling said drive means and for calculating a cardiac output value as a function of sensed temperature changes in response to injection of said liquid bolus into said vascular system, and output means for displaying the resultant calculated cardiac output value,

first operator controlled input means for selecting the quantity of injectate to be discharged from said chamber,

second operator controlled input means for actuating said injection apparatus to discharge injectate from said chamber into said lumen of said catheter, and third operator controlled input means for varying the distribution rate of said stepping pulses to change the rate at which injectate is discharged from said chamber.

9. The system of claim 8 and further including fourth operator controlled input means for drawing the volume of injectate selected by said first operator controlled input means into said chamber from an external reservoir.

10. The system of claim 9 wherein said chamber includes a cylinder and a piston disposed in said cylinder for axial movement therein, and said drive means is coupled to said piston, said drive means moving said piston to increase the volume of said chamber to draw injectate into said chamber from said external reservoir and to decrease the volume of said chamber to discharge injectate from said chamber.

11. The system of claim 10 for use with a plural lumen catheter that has one lumen which provides a bolus flow path to said port, and further including a second sensor at said proximal end of said catheter and means for transmitting signals from said thermal and second sensors to said processor means.

12. The system of claim 11 wherein said processor means includes delay means responsive to said second operator controlled input means for commencing integration over an interval of time of the departure from base line of temperature sensed by said thermal sensor carried by said catheter and fault sensitive means responsive to either of said sensors for interrupting discharge of injectate from said chamber in response to a detected sensor defect.