Patient monitoring equipment, probe for use therewith, and method of measuring anesthesia based on oesophagal contractions

• US 4,502,490 A
• Filed: 10/23/1981
• Issued: 03/05/1985
• Est. Priority Date: 10/28/1980
• Status: Expired due to Fees

• Current Assignee: Antec Systems Limited
• Original Assignee: Antec Systems Limited
• Inventors: Evans, John M., Wise, Colin C.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/314,413
• Time in Patent Office: 1,229 Days
• Field of Search: 128/721, 128/733, 128/739, 128/741, 128/747, 128/748, 128/774, 128/780, 128/782, 128/630
• US Class Current: 600/593
• CPC Class Codes: A61B 5/037 Measuring oesophageal pressure
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0415 with access means to the stomach
• CPC Class Codes: A61M 16/0438 Liquid-filled
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 25/10181 Means for forcing inflation fluid into the balloon
• CPC Class Codes: A61M 25/10184 Means for controlling or monitoring inflation or deflation
• CPC Class Codes: A61M 25/10185 Valves
• CPC Class Codes: A61N 1/0517 Esophageal electrodes
• CPC Class Codes: A61N 1/0519 Endotracheal electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

A method of monitoring the depth of anaesthesia of a patient, comprising stimulating contractions in the oesophagus of the patient, for example using an inflatable oesophageal balloon, obtaining signals indicative of the oesophageal contractions using a sensor, and deriving from the signals an output indicative of the rate of occurrence of signals having a magnitude greater than a preset threshold value, and apparatus for carrying out the method.

An alternative aspect comprises assigning a score value to each of a plurality of different bodily functions of a patient, for example heart rate, blood pressure, degree of sweating, and formation of tears, the said score values being indicative of a depth of anaesthesia or sedation, summing the score values, and producing an output from the summed score values indicative of the amount of anaesthetic to be fed to the patient.

Claims

1. Patient monitoring apparatus, comprising a sensor for providing signals indicative of smooth muscle contractions in the oesophagus of a patient, means for deriving from the said signals an output indicative of the depth of anaesthesia of a patient, and means adapted to connect said output deriving means to a device which operates in response to said derived output.

2. Apparatus as claimed in claim 1, including discriminating means for accepting only signals of more than a desired threshold magnitude to eliminate signals arising out of non-oesophageal activities.

3. Apparatus as claimed in claim 2, wherein the said threshold magnitude is greater than the magnitude of signals produced by forced ventilation of the lungs of the patient.

4. Apparatus as claimed in claim 2, further including means for defining a preset time window during which oesophageal contractions are measured, and means for continuously measuring the number of oesophageal contractions greater than said desired threshold magnitude which occur within said preset time window.

5. Apparatus as claimed in claim 1, including means for stimulating contractions in the oesophagus of the patient.

6. Apparatus as claimed in claim 5, wherein the means for stimulating contractions in the oesophagus comprise a balloon insertable into the oesophagus or the trachea and means for applying pressure to the balloon.

7. Apparatus as claimed in claim 4, including means for supressing stimulation of the oesophagus on detection of spontaneous oesophageal contractions by the sensor.

8. Apparatus as claimed in claim 1 wherein said means deriving an output indicative of the anaethesia depth includes means for producing an output indicative of the rate of occurrence of oesophageal contractions.

9. Apparatus as claimed in claim 1, which apparatus includes means for selectively rejecting any signal at the discretion of the operator of the apparatus.

10. Apparatus as claimed in claim 1, wherein the sensor includes a balloon insertable into the oesophagus of the patient, and transducer means for producing an electrical signal in response to pressure changes in said space in the balloon.

11. Apparatus as claimed in claim 1 further including means for automatically rejecting signals of less than a predetermined duration.

12. Patient monitoring apparatus as in claim 1, which further comprises means for assigning a score value to each of a plurality of different bodily functions of a patient, the said score values being indicative of a depth of anaesthesia or sedation and one of the said score values being indicative of contractions in the oesophagus, means for summing the score values, and means for producing an output from the summed score values indicative of the amount of anaesthetic to be fed to the patient.

13. Apparatus as claimed in claim 12, including means for prompting the entry by a clinician of a score value.

14. Apparatus as claimed in claim 12, wherein the bodily functions include heart rate, blood pressure, degree of sweating, and formation of tears.

41. A probe as claimed in claim 4 wherein the said points are spaced from each other by from 10 to 15 cm.

45. Apparatus as claimed in claim 14, including means for measuring at least one of the said bodily functions.

15. Apparatus for controlling the amount of an anaesthetic administered to a patient comprising sensor means for providing signals indicative of contractions in the oesophagus of a patient, means for deriving from said signals an output indicative of the depth of anaesthesia of a patient, and means for automatically controlling the amount of an anaesthetic administered to a patient in response to variation in the output indicative of the depth of anaesthesia.

16. Apparatus for monitoring the depth of anaesthesia of a patient, which apparatus comprises means for stimulating contractions in the oesophagus of the patient, a sensor for providing signals indicative of the oesophageal contractions, discriminating means for accepting only signals of more than a preset threshold magnitude to eliminate signals arising from non-aesophageal activities, and means for deriving from the signals an output indicative of the rate of occurrence of signals having a magnitude greater than said preset threshold magnitude.

17. A method of monitoring the depth of anaesthesia in a patient, which method comprises the steps of (a) deriving signals indicative of contraction in the oesophagus of the patient, and (b) deriving from the said signals an output indicative of the depth of anaesthesia of the patient.

18. A method as claimed in claim 17, wherein step (b) further includes the step of deriving the output only from signals having a magnitude greater than a desired threshold value.

19. A method as claimed in claim 17, wherein step (b) further includes the step of deriving the output from the rate of occurrence of the said oesophageal contractions.

20. A method as claimed in claim 17 further comprising the step of (c) applying a stimulus to the patient to provoke contractions in the oesophagus.

21. A method of controlling the depth of anaesthesia of a patient, which method comprises the steps of (a) deriving signals indicative of contractions in the oesophagus of the patient, (b) deriving from the signals an output indicative of the depth of anaesthesia of the patient, and (c) controlling the administration of anaesthetic or sedative drugs to the patient in response to the said output.

23. A method as claimed in claim 21, wherein step (b) further includes the step of deriving the output.

24. A method as claimed in claim 21 further comprising the step of (d) applying a stimulus to the patient to provoke contractions in the oesophagus.

22. A method as claimed 21, wherein step (b) further includes the step of deriving the output only from signals having a magnitude greater than a desired threshold value.

25. An elongate probe for measuring oesophogeal contractions, having a distal end adapted to pass downwardly through the oesophagus of the patient, and a proximal end adapted in use to lie externally of the mouth of the patient, the probe including stimulating means adapted in use to lie within the oesophagus of a patient and operable by means external to the patient for stimulating the oesophagus, to cause contractions therein, pressure sensing means adapted in use to lie within the oesophagus of the patient for enabling the measurement of pressure within the oesophagus, thereby to sense contractions of the oesophagus.

26. A probe as claimed in claim 25 wherein the stimulating means comprises a sealed inflatable balloon, and the probe comprises a lumen in fluid communication between the balloon and the proximal end of the probe.

27. A probe as claimed in claim 26 wherein the maximum diameter of the inflatable balloon is about 2 cm.

28. A probe as claimed in claim 27 wherein the stimulating means comprises two inflatable balloons spaced along the probe.

29. A probe as claimed in claim 28 including means to cause the two inflatable stimulating balloons to expand at differing rates.

30. A probe as claimed in claim 25 wherein the stimulating means includes a pair of electrodes on the probe, and means for supplying an electrical voltage to the electrodes.

31. A probe as claimed in claim 30 wherein the pressure sensing balloon includes a foam insert to maintain the balloon volume.

32. A probe as claimed in claim 25 wherein the pressure sensing means includes an inflatable sensing balloon.

33. A probe as claimed claim 32 including a lumen in fluid communication between the said sensing ballon and means on the proximal end of the tube for the connection of a pressure transducer.

34. A probe as claimed in claim 32 wherein the maximum diameter of the sensing balloon is about 2 cm.

35. A probe as claimed in claim 32 wherein the sensing balloon has a length of from 3 to 5 cm.

36. A probe as claimed in claim 32 wherein a small leak is provided to permit the equalisation of permanent pressure changes in the sensing balloon.

37. A probe as claimed in claim 32 which also incorporate a sealed inflatable stimulating balloon as defined in claim 26.

38. A probe as claimed in claim 37 wherein the stimulating balloon and the sensing balloon are concentric.

39. A probe as claimed in claim 25 including a pressure transducer adapted in use to lie in the oesophagus of the patient.

40. A probe as claimed in claim 25 including means for sensing the pressure at two points spaced along the oesophagus.

42. A probe as claimed in claim 25 including a microphone or a temperature sensor.

43. A probe for measuring oesophogeal contractions, comprising an elongate body portion for insertion into the oesophagus and having at least first and second lumens sealed with respect to each other, the first lumen being in communication at its distal end with a sensing balloon for sensing oesophageal pressure, and being provided at its proximal end with means for connection to a pressure measuring device, and the second lumen being adapted to receive a fluid under pressure to stimulate the oesophagus to cause contractions therein.

44. Patient monitoring apparatus, which comprises means for assigning a score value to each of a plurality of different bodily functions of a patient, the said score values being indicative of a depth of anaesthesia or sedation, means for summing the score values, and means for producing an output from the summed score values indicative of the amount of anaesthetic to be fed to the patient.

46. Apparatus as claimed in claim 44, including means for prompting the entry by a clinician of a score value.

47. Apparatus as claimed in claim 44, including means for automatically controlling the amount of anaesthetic delivered to the patient in response to the said output.

48. Apparatus as claimed in claim 47, wherein the bodily functions include heart rate, blood pressure, degree of sweating, and formation of tears.

49. A method of monitoring the depth of anaesthesia of a patient, which method comprises assigning a score value to each of a plurality of different bodily functions, the said score values being indicative of a depth of anaesthesia, and summing the score values to obtain a total score indicative of the depth of anaesthesia of the patient.