Infrared optical measurement of blood gas concentrations and fiber optic catheter

• US 4,509,522 A
• Filed: 12/15/1981
• Issued: 04/09/1985
• Est. Priority Date: 12/15/1981
• Status: Expired due to Fees

• Current Assignee: the united states of america as represented by the secretary of the navy
• Original Assignee: the united states of america as represented by the secretary of the navy
• Inventors: Manuccia, Thomas J., Eden, J. Gary
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Sykes, Angela D.
• Application Number:
  US06/331,091
• Time in Patent Office: 1,211 Days
• Field of Search: 128/632-635, 128/637, 128/664, 128/303.1, 356/39-42, 204/195 B, 204/403
• US Class Current: 600/326
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6848 Needles

Abstract

A simple compact optical device and method for quickly measuring the concentration of CO and CO₂, bound to hemoglobin or dissolved in a person'"'"'s blood using optical techniques which do not require removing a blood sample from the body. It also provides a simple fiber optic device for measuring blood-gas concentrations of critical internal points of the circulatory system such as the aorta.

Claims

1. A method of determining the absolute concentrations of CO, CO₂ and O₂ in blood comprising the steps of:

selectively passing infrared light of near 5.13 μ

m, 4.3 μ

m and 9.0 μ

m through a dimension of blood and measuring magnitudes of transmission at absorption peak wavelengths near 5.13 μ

m, 4.3 μ

m and 9.0 μ

m, corresponding to CO, CO₂, and O₂, respectively;

comparing said respective transmissions to transmissions through like dimension reference samples of blood whose blood gas concentrations are known;

determining the absolute concentrations of CO, CO₂, and O₂, biased on the comparison of transmission through the blood dimension at these wavelengths to transmission through the reference blood samples having known concentrations of CO, CO₂, and O₂.

2. A method of detecting relative concentrations of CO, CO₂, and O₂ in blood comprising the steps of:

passing infrared radiation through a dimension of blood, said infrared radiation exiting from the backside of the blood dimension;

selectively filtering at near 5.13 μ

m, 4.3 μ

m and 9.0 μ

m the radiation passing from the backside of the blood dimension;

measuring the amplitude of the filtered radiation at absorption peak wavelengths of 5.13 μ

m, 4.3 μ

m and 9.0 μ

m as an indication of relative concentration for CO, CO₂, and O₂, respectively.

3. A method of determining absolute concentrations of CO, CO₂, and O₂ in blood comprising the steps of:

passing infrared radiation through a thin section of blood-containing body tissue;

selectively filtering at 5.13 μ

m, 4.3 μ

m and 9.0 μ

m wavelengths radiation exiting from the body tissue;

measuring respective amplitudes of the filtered radiation at absorption peak wavelengths of 5.13 μ

m, 4.3 μ

m and 9.0 μ

m; and

comparing the measured respective amplitudes obtained from measuring like wavelength radiation having passed through similar sections of human body tissues whose blood concentration of CO, CO₂, and O₂ are known;

detemining the absolute concentrations of CO, CO₂, and O₂ based on the comparison of the radiation passed through the body tissue at these wavelengths to the radiation passed through the body tissues having known concentrations of CO, CO₂ and O₂.

4. Apparatus for indicating relative concentration of CO in blood comprising:

means for directing infrared light through relatively thin blood containing tissue of the human body;

filter means allowing a bandpass of around 5.13 μ

m;

said filter means adapted to be located on the backside of the tissue for intercepting light exiting from the tissue; and

light detector means for detecting the magnitude of light having passed through said filter means at absorption peaks of around 5.13 μ

m;

whereby the magnitude of light detected by said detector means is proportional to the concentration of carbon monoxide in the blood.

5. Apparatus for indicating the absolute concentration of carbon monoxide in blood comprising:

means for directing light through a relatively thin blood-containing human body tissue;

means adapted to be located on the backside of the body tissue for intercepting light exiting from the tissue and splitting the light into two beams of substantially equal magnitude;

first filter in one of the beams allowing a bandpass of about 5.13 μ

m;

second filter in the other beam allowing a bandpass of around 5.05 μ

m; and

light detecting means downstream of the first and second filters for detecting light transmitted thereto from the filters;

whereby the extent of around 5.05 μ

m wavelength light transmission through the blood-containing human body tissue is relatively independent of carbon monoxide concentration in the blood, but is dependent upon other characteristics of that body tissue for establishing a reference; and

whereby the extent of light of around 5.13 μ

m wavelengths transmitted through the same blood-containing body tissue defines a carbon monoxide concentration when compared with the reference transmission.

6. A method of detecting absolute concentrations of CO, CO₂, and O₂ in blood comprising the steps of:

passing infrared radiation through a dimension of blood;

selectively filtering at near 5.13 μ

m, 4.3 μ

m and 9.0 μ

m the radiation passing from the backside of said blood dimension;

measuring the respective amplitudes of the filtered radiation at absorption peak wavelengths near 5.13 μ

m, 4.3 μ

m and 9.0 μ

m; and

comparing the measured amplitudes against amplitudes obtained by like radiation wavelengths having passed through a like dimension of blood whose CO, CO₂ and O₂ concentrations are known;

detecting the absolute concentrations of CO, CO₂, and O₂ based on the comparison of the radiation passed through the blood dimension at these wavelength to the radiation passed through a blood dimension having known concentrations of CO, CO₂, and O₂.