Oral compositions

• US 4,512,968 A
• Filed: 11/23/1983
• Issued: 04/23/1985
• Est. Priority Date: 11/30/1982
• Status: Expired due to Fees

• Current Assignee: Lion Corporation
• Original Assignee: Lion Corporation
• Inventors: Itoi, Hiroshi, Komiyama, Noboru, Sano, Hiroshi
• Primary Examiner(s): Rose; Shep K.
• Application Number:
  US06/555,111
• Time in Patent Office: 517 Days
• Field of Search: 424/48-58,180
• US Class Current: 424/48
• CPC Class Codes: A61K 8/736 Chitin; Chitosan; Derivatives thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Chitin or chitin derivatives compounded with oral compositions such as dentifrice, mouth rinse, oral freshener, chewing gum and the like exhibit superior medicine effects for the prevention of dental caries, periodontoclasia and mouth odor. And, chitosan salt is also effective as the binding agent for use in the above mentioned oral compositions.

Claims

1. A composition for reducing dental caries, periodontoclasia and mouth odor, comprising an amount of at least 0.01 wt.% of a material selected from the group consisting of chitin, chitosan, pharmaceutically acceptable acid salts of chitosan and mixtures thereof, effective to reduce the incidence or severity of dental caries, periodontoclasia and mouth odor, said material being compounded in a dentifrice, toothpaste, tooth powder, liquid dentifrice, mouth rinse, oral freshener or chewing gum composition.

3. A composition as claimed in claim 1 in which said composition is a toothpaste containing from 0.01 to 70 wt.% of chitin, chitosan or mixture thereof.

4. A composition as claimed in claim 1 in which said composition is a tooth powder containing from 0.01 to 97 wt.% of chitin, chitosan or mixture thereof.

5. A composition as claimed in claim 1 in which said composition is a solid oral freshener containing from 0.01 to 70 wt.% of chitin, chitosan or mixture thereof.

6. A composition as claimed in claim 1 in which said composition is a liquid composition containing from 0.01 to 20 wt.% of chitin, chitosan or mixture thereof.

7. A composition as claimed in claim 1 in which said composition is a chewing gum containing from 0.01 to 60 wt.% of chitin, chitosan or mixture thereof.

8. A composition as claimed in claim 1 effective for treating periodontoclasia containing at least about 0.01 wt.% of a pharmaceutically acceptable acid salt of chitosan.

9. A composition as claimed in claim 8 in which said acid salt is the hydrochloric acid salt of chitosan.

10. A composition as claimed in claim 8 in which said acid salt is selected from the group consisting of the acetic acid, lactic acid, citric acid, malic acid and maleic acid salts of chitosan.

2. A composition for reducing dental caries, periodontoclasia and mouth odor, comprising a material selected from the group consisting of chitin, chitosan, pharmaceutically acceptable acid salts of chitosan and mixtures thereof, in an amount of at least 0.01 wt.%, effective to reduce the incidence or severity of dental caries, periodontoclasia and mouth odor, in association with a pharmaceutically acceptable dentifrice composition.