Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it

• US 4,514,421 A
• Filed: 09/14/1982
• Issued: 04/30/1985
• Est. Priority Date: 08/30/1979
• Status: Expired due to Term

• Current Assignee: Cardinal Associates, Inc. (Balchem Corporation)
• Original Assignee: Robert J. Herschler
• Inventors: Herschler, Robert J.
• Primary Examiner(s): FRIEDMAN, STANLEY
• Application Number:
  US06/418,110
• Time in Patent Office: 959 Days
• Field of Search: 424/337
• US Class Current: 514/711
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methylsulfonylmethane (CH₃ SO₂ CH₃) administered orally is effective in ameliorating the symptoms of gastrointestinal upset, e.g., produced by the ingestion of aspirin and other pharmaceuticals, and of allergic reactions. Oral compositions containing a mixture of such a pharmaceutical and methylsulfonylmethane are useful in avoiding the gastrointestinal upset which otherwise occurs when ingesting the former.

Claims

1. A method for ameliorating the symptoms associated with physiological response to stress comprising at least one of gastrointestinal upset and inflammation of the mucous membranes which comprises orally administering to a patient manifesting such symptoms an amount of methylsulfonylmethane effective to ameliorate those symptoms.

2. A method according to claim 1 wherein the patient is a human being.

3. A method according to claim 1 wherein the patient manifests symptoms of gastrointestinal upset which include one or more of nausea, irregular bowel movements, gastric pain and hyperacidity.

4. A method according to claim 1 wherein the methylsulfonylmethane is administered in a plurality of daily dosages.

5. A method according to claim 1 wherein the amount of methylsulfonylmethane administered per dosage is from about 100 mg. to 1,000 mg.

6. A method according to claim 1 wherein the amount of methylsulfonylmethane administered per dosage is from about 250 mg. to 500 mg.

7. A method according to claim 1 wherein the patient is a human being manifesting symptoms of gastrointestinal upset comprising one or more of nausea, irregular bowel movements, gastric pain and hyperacidity and the methylsulfonylmethane is administered at dosages of about 100 mg. to 1,000 mg. per dosage.

8. A method according to claim 7 wherein the amount of methylsulfonylmethane administered per dosage is from about 250 mg. to 500 mg.

17. A method according to claim 7 wherein the total daily dosage is 250-2,000 mg.

9. A method for ameliorating allergic symptoms which comprises orally administering to a patient manifesting such symptoms an amount of methylsulfonylmethane effective to ameliorate those symptoms.

10. A method according to claim 9 wherein the patient is a human being.

11. A method according to claim 9 wherein the symptoms comprise one or more of mucous membrane inflammation or irritation, skin rash, hives and respiratory congestion.

12. A method according to claim 9 wherein the methylsulfonylmethane is administered in a plurality of daily dosages.

13. A method according to claim 9 wherein the amount of methylsulfonylmethane administered per dosage is from about 100 mg. to 1,000 mg.

14. A method according to claim 9 wherein the amount of methylsulfonylmethane administered per dosage is from about 250 mg. to 500 mg.

15. A method according to claim 9 wherein the patient is a human being whose symptoms comprise one or more of mucous membrane inflammation or irritation, skin rash, hives and respiratory congestion, diarrhea and hyperacidity and the methylsulfonylmethane is administered at dosages of about 100 mg. to 1,000 mg. per dosage.

16. A method according to claim 15 wherein the amount of methylsulfonylmethane administered per dosage is from about 250 mg. to 500 mg.

18. A method according to claim 15 wherein the total daily dosage is 250-2,000 mg.