Powder syringe mixing system

• US 4,515,586 A
• Filed: 11/30/1982
• Issued: 05/07/1985
• Est. Priority Date: 11/30/1982
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Mendenhall, Douglas W., Li, Ping
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Lester, Michelle
• Application Number:
  US06/445,399
• Time in Patent Office: 889 Days
• Field of Search: 604/56, 604/82, 604/87-89, 604/90-92, 604/, 604/410, 604/416, 604/415, 604/244, 604/403, 604/414
• US Class Current: 604/87
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed

Abstract

A pre-filled chamber having a piston plug at one end and a stopper at the other end. The chamber is filled with a powdered medicament that is to be intermixed with a diluent in a container. Rotatable attachments join the chamber containing the powder with a receptacle on the container. The powdered medicament is expelled from the chamber by the force of a plunger acting on the piston plug. The stopper at the end of the chamber containing the powder serves as a mounting for a piercing tip which breaks a membrane over the neck of the container allowing fluid connection between the chamber and the container and transferral of the powdered medicament from the chamber to the container.

Claims

1. A mixing system for first storing and subsequently transferring a powdered medicament to a solution container comprising:

a hollow chamber member;

a piston plug slidably mounted in sealing engagement with one end of said hollow chamber member;

a stopper member slidably mounted in the opposite end of said hollow chamber member from said piston plug, said stopper member having a piercing tip on one side thereof;

external rotatable engagement means extending from said hollow chamber member substantially adjacent said stopper member;

complementary internal rotatable engagement means in the neck portion of the solution container;

removable means for exerting force on said piston plug in a direction substantially parallel to the axis of said hollow chamber member;

a rupturable diaphragm positioned in the neck portion of the solution container so that rotatable engagement of said external and internal rotatable engagement means will cause said piercing tip to rupture said pierceable diaphragm;

whereby the exertion of force on said piston plug by said removable means for exerting force after the rupturing of said rupturable diaphragm by said piercing tip will effect a transfer of the powdered medicament from said hollow chamber member into the solution container.

2. The syringe mixing system as defined in claim 1 wherein the ends of the hollow chamber member are covered by sealing caps.

3. The mixing system as defined in claim 1 wherein said hollow chamber member is formed from plastic material.

4. The mixing system as defined in claim 1 wherein the rotatable engagement means are threads.

5. The mixing system as defined in claim 1 wherein the removable means for exerting force on said piston plug in a direction substantially parallel to the axis of said chamber member comprises a plunger assembly.

6. A plunger activated vial for first storing and subsequently transferring a powdered medicament to a solution container having an internal rotatable attachment element and a rupturable diaphragm in a neck portion, said plunger activated vial comprising:

a hollow chamber member;

piston plug slideably mounted in sealing engagement with said hollow chamber member;

a stopper member slidably mounted in sealing engagement with the opposite end of said hollow chamber member from said piston plug, said stopper member defining a piercing tip;

an external rotatable attachment element extending from said hollow chamber member substantially adjacent said stopper member, said external rotatable attachment element being complementary to the internal rotatable attachment element of the solution container so that rotatable interengagement of the rotatable attachment elements will cause said piercing tip to rupture said diaphragm; and

a plunger assembly comprising;

means for attaching said plunger assembly to said hollow chamber member adjacent said piston plug;

a piston member constructed and arranged to contact said pushing plug;

a pushing surface constructed and arranged for the application of manual force;

a shaft member connecting said piston member and said pushing surface;

whereby upon the application of manual force on said pushing surface of said plunger assembly in the direction of said hollow chamber member, after the rupturing of the diaphragm by the piercing tip, said piston member will cause the movement of said piston plug into said hollow chamber member and cause said powdered medicament to be transferred into the solution container.

7. The plunger-activated vial as defined in claim 6 wherein said external rotatable attachment is defined by threads.

8. The plunger activated vial as defined in claim 6 wherein said piercing tip is formed separately from said stopper member.