Wet-dry compartmental syringe

• US 4,516,967 A
• Filed: 07/27/1983
• Issued: 05/14/1985
• Est. Priority Date: 12/21/1981
• Status: Expired due to Term

• Current Assignee: M.R.I. Investment S.A.
• Original Assignee: Rudolph J. Kopfer
• Inventors: Kopfer, Rudolph J.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US06/517,050
• Time in Patent Office: 657 Days
• Field of Search: 604/82, 604/86-92, 604/200, 604/201
• US Class Current: 604/87
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

An improved syringe incorporating a solid powdered medicament and a dissolving fluid in a compact manner utilizes a compartment for the solid material which may be readily packaged commercially and an arrangement whereby fluid and solid components may be mixed and the latter dissolved while maintaining complete hermetically sealed conditions for all components including the injection needle until the latter is ready for injecting into the patient or intravenous device. This is accomplished by a specially constructed tube which surrounds and seals the syringe barrel, injection needle, and medicament and diluent until ready for use. Added features are rigidity, simplicity and economy in manufacture, safety against malfunction and simplicity in operation by customarily trained personnel.

Claims

1. A completely enclosed compartmental syringe disposed for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said seal;

said tube enclosing the entire syringe and forming a hermetically sealed compartment therefor;

said tube being made of flexible plastic material;

said tube being disposed for limited axial movement along the outside of said seal while maintaining tight contact therewith;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal joining said barrel and said tube;

a hypodermic needle having its first end positioned on one end of said barrel within said tube and connecting with the interior of said barrel;

a second end of said needle being positioned hermetically against said puncturable seal within said tube and partially penetrating said puncturable seal thus maintaining a seal on the interior of said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said liquid solvent;

means for simultaneously advancing said tube and said barrel towards said puncturable seal on said container until said second end of said needle punctures said puncturable seal;

means for advancing said plunger in said barrel and discharging said solvent into said container thereby causing said powdered medicament to dissolve;

means for withdrawing said plunger thereby sucking such dissolved medicament into said barrel; and

means for removing said barrel together with said plunger and said needle from said tube,

said tube preventing contact between moving parts of said syringe with the outside atmosphere.

7. The device of claim 1 or claim 2 or claim 3 in which said means for advancing and withdrawing said tube comprises a flange positioned at the end of said tube.

8. The device of claim 1 or claim 2 or claim 3 in which said means for advancing and withdrawing said plunger in said syringe barrel comprises a flange positioned at the end of a stem on said plunger.

9. The device of claim 1 or claim 2 or claim 3 in which the hermetic seal between said barrel and said tube is equipped with a tear tab to facilitate its easy removal when it is desired to move said barrel relative to said tube.

10. The device of claim 1 or claim 2 or claim 3 including stop means positioned on said barrel and said tube to limit the movement of said barrel in said tube to a predetermined position.

11. The device of claim 1 or claim 2 or claim 3 in which said puncturable elastomeric seal on said container is equipped with an opening on its surface disposed to hermetically receive and guide one end of said needle while said needle punctures said seal.

2. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storing a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material on an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal, the tube being disposed for limited axial movement along the outside of the seal while maintaining tight contact therewith;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said barrel and said tube;

a hypodermic needle having a first end positioned on one end of said barrel and communicating with the interior thereof;

a second end of said needle being positioned hermetically with said puncturable seal on said container;

means for advancing said syringe barrel towards said puncturable seal on said container until said second end of said needle punctures said puncturable seal;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said mixed medicament into said container; and

means for removing said barrel together with said plunger and said needle from said tube.

3. A compartmental syringe disposed for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament having a spherical end and an open end;

a hollow puncturable seal of elastomeric material engaging said open end and having a projecting end within said container of generally conical configuration;

a hollow tube of elastomeric material positioned within said seal;

said tube tightly engaging said seal and said open end of said container;

said tube projecting beyond the open end of said container;

a syringe barrel slidably mounted within said tube;

a removable hermetic seal between said tube and said syringe barrel;

a hypodermic needle having one end positioned against said barrel and communicating with the interior thereof;

the other end of said needle being positioned hermetically against the interior of said projecting end of said seal;

means for advancing said barrel in said tube towards said puncturable seal in said container until said needle punctures said puncturable seal;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container to mix the solvent with said powdered medicament;

means for withdrawing said plunger thereby sucking said mixed medicament into said barrel; and

means for removing said barrel together with said plunger and said needle from said tube.

4. A compartmental syringe disposed for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube.

5. A completely enclosed compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said seal;

said tube enclosing the entire syringe and forming a hermetically sealed compartment therefor, said tube being made of flexible plastic material and being disposed for limited axial movement along the outside of said seal while maintaining tight contact therewith;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal joining said barrel and said tube;

a hypodermic needle having its first end positioned on one end of said barrel within said tube and connecting with the interior of said barrel;

a second end of said needle being positioned hermetically against said puncturable seal within said tube and partially penetrating said puncturable seal thus maintaining a seal on the interior of said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said liquid solvent;

means for simultaneously advancing said tube and said barrel towards said puncturable seal on said container until said second end of said needle punctures said puncturable seal;

means for advancing said plunger in said barrel and discharging said solvent into said container thereby causing said powdered medicament to dissolve;

means for withdrawing said plunger thereby sucking such dissolved medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube,

said tube preventing contact between moving parts of said syringe with the outside atmosphere, said hollow tube including an enlarged cylindrical section at one end;

said section being equipped with inwardly projecting annular sections;

said sections being disposed for tightly engaging a metallic band;

said band being disposed for tightly engaging a flanged edge of said seal with a flanged edge of said opening in said container; and

said sections being further disposed for maintaining tight contact between said container, said metallic band and the interior of said enlarged section when said tube is moved axially to a position wherein said needle pierces said seal.

6. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storing a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material on an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal, the tube being disposed for limited axial movement along the outside of the seal while maintaining tight contact therewith;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said barrel and said tube;

a hypodermic needle having a first end positioned on one end of said barrel and communicating with the interior thereof;

a second end of said needle being positioned hermetically with said puncturable seal on said container;

means for advancing said syringe barrel towards said puncturable seal on said container until said second end of said needle punctures said puncturable seal;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container to dissolve said powdered medicament;

means for withdrawing said plunger thereby sucking said mixed medicament into said container;

means for removing said barrel together with said plunger and said needle from said tube;

a flange around the periphery of said puncturable seal;

a flange around the periphery of said opening in said container;

a flange around the end of said hollow tube adjacent said container; and

a metallic clamp engaging said flanges to effect a tight seal therebetween.

12. A compartmental syringe for storing and mixing two separate medicaments at least one of which medicaments is a liquid comprising:

a container for storing of a predetermined quantity of one of said medicaments;

said container having a flanged neck portion defining an access opening into the container;

a puncturable seal of elastomeric material sealing said opening in said container;

a hollow tube having one end portion operatively engaging said flanged neck portion of said container and enclosing said puncturable seal within said tube;

a syringe barrel slidably positioned within another end portion of said tube in spaced relation from said container, said barrel containing a predetermined amount of a second one of said medicaments;

needle means carried by one end of said barrel and having a point on at least one end thereof;

means for moving said syringe barrel and said container relative to each other in said tube until said point on said needle punctures said puncturable seal;

a plunger slidably mounted within said barrel;

means for moving said plunger in said barrel for discharging one of said medicaments through said needle into mixing relation with the second of said medicaments;

means for removing said barrel together with said plunger and said needle from said tube;

wherein the needle means is a double ended hypodermic needle positioned within the tube;

said point on one end of said needle being positioned against said puncturable seal on said container and partially penetrating said puncturable seal;

a puncturable disc sealing the one of said barrel,

a second end of said needle positioned against the puncturable disc;

means for moving said barrel relative to said container whereby said puncturable seal and said puncturable disc are punctured simultaneously;

means for advancing said plunger in said barrel and discharging the medicament in the barrel into the medicament in said container;

thereby permitting said two medicaments to mix with each other;

means for withdrawing said plunger thereby sucking such mixed medicament into said barrel; and

means for removing said barrel together with said plunger and needle from said tube;

said tube preventing contact between moving parts of said syringe and the outside atmosphere.

13. A compartmental syringe for storing two separate medicaments at least one of which is a liquid medicament and mixing said medicaments prior to injection comprising:

a container for storing a predetermined quantity of one of said medicaments;

a puncturable seal of elastomeric material sealing an opening in said container;

a hollow tube having one end portion operatively engaging said container and sealingly enclosing the puncturable seal;

a syringe barrel slidably positioned in another end portion of said tube, said barrel containing a predetermined amount of a second one of said medicaments;

needle means carried by one end of said barrel and having a point on at least one end thereof;

said point on said needle being sealed by said puncturable seal on said container;

means for moving said syringe barrel and said container relative to each other until said point on said needle punctures said puncturable seal and establishes communication between said container and said barrel;

a plunger slidably mounted within said barrel;

means for moving said plunger in said barrel for expelling one of said medicaments through said needle into mixing relation with the other of said medicaments; and

means for removing said barrel together with said plunger and said needle from said tube;

wherein said one end portion of said tube includes stop means axially spaced apart an amount equal to at least the penetrating thickness of the puncturable seal; and

wherein when said syringe barrel is moved relative to said container the end end portion of the tube expands so that one stop means on the tube moves past the enclosed puncturable seal on the container as the point of the needle penetrates the puncturable seal.

14. A compartmental syringe for storing two separate medicaments at least one of which is a liquid medicament and mixing said medicaments prior to injection comprising:

a container for storing a predetermined quantity of one of said medicaments;

a puncturable seal of elastomeric material sealing an opening in said container;

a hollow tube having one end portion operatively engaging said container and sealingly enclosing the puncturable seal;

a syringe barrel slidably positioned in another end portion of said tube, said barrel containing a predetermined amount of a second one of said medicaments;

needle means carried by one end of said barrel and having a point on at least one end thereof;

said point on said needle being sealed by said puncturable seal on said container;

means for moving said syringe barrel and said container relative to each other until said point on said needle punctures said puncturable seal and establishes communication between said container and said barrel;

a plunger slidably mounted within said barrel;

means for moving said plunger in said barrel for expelling one of said medicaments through said needle into mixing relation with the other of said medicaments; and

means for removing said barrel together with said plunger and said needle from said tube;

wherein said tube is sealingly fixed to the end of said puncturable seal and to the container and wherein said barrel moves relative to said tube to advance the needle to penetrate the puncturable seal.

15. A compartmental syringe for storing two separate medicaments at least one of which is a liquid medicament and mixing said medicaments prior to injection comprising:

a container for storing a predetermined quantity of one of said medicaments;

a puncturable seal of elastomeric material sealing an opening in said container;

a hollow tube having one end portion operatively engaging said container and sealingly enclosing the puncturable seal;

a syringe barrel slidably positioned in another end portion of said tube, said barrel containing a predetermined amount of a second one of said medicaments;

needle means carried by one end of said barrel and having a point on at least one end thereof;

said point on said needle being sealed by said puncturable seal on said container;

means for moving said syringe barrel and said container relative to each other until said point on said needle punctures said puncturable seal and establishes communication between said container and said barrel;

a plunger slidably mounted within said barrel;

means for moving said plunger in said barrel for expelling one of said medicaments through said needle into mixing relation with the other of said medicaments; and

means for removing said barrel together with said plunger and said needle from said tube;

wherein said container has a spherical shaped end and wherein said puncturable seal has an end projecting within the container;

said tube being positioned in said seal and said syringe barrel being slidable in said tube;

said syringe barrel being moved axially toward the container to penetrate the puncturable seal.

16. A compartmental syringe for storing two separate medicaments at least one of which is a liquid medicament and mixing said medicaments prior to injection comprising:

a container for storing a predetermined quantity of one of said medicaments;

a puncturable seal of elastomeric material sealing an opening in said container;

a hollow tube having one end portion operatively engaging said container and sealingly enclosing the puncturable seal;

a syringe barrel slidably positioned in another end portion of said tube;

said barrel containing a predetermined amount of a second one of said medicaments;

needle means carried by one end of said barrel and having a point on at least one end thereof;

said point on said needle being sealed by said puncturable seal on said container;

means for moving said syringe barrel and said container relative to each other until said point on said needle punctures said puncturable seal and establishes communication between said container and said barrel;

a plunger slidably mounted within said barrel;

means for moving said plunger in said barrel for expelling one of said medicaments through said needle into mixing relation with the other of said medicaments;

means for removing said barrel together with said plunger and said needle from said tube;

wherein said needle is a double ended needle with one end poised in alignment with a penetrating disc over the end of the syringe barrel and with the other end poised in alignment with the puncturable seal on the container, said needle being carried by the end portion of the syringe barrel for axial movement relative to the barrel; and

wherein the movement of the barrel relative to the container moves the two ends of the needles through the penetrating disc and puncturable seal to establish communication between the barrel and the container.

17. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament having a spherical end and an open end;

a hollow puncturable seal of elastomeric material engaging said open end and having a projecting end within said container of generally conical configuration;

a hollow tube of elastomeric material positioned within said seal;

said tube tightly engaging said seal and said open end of said container;

said tube projecting beyond the open end of said container;

a syringe barrel slidably mounted within said tube;

a removable hermetic seal between said tube and said syringe barrel;

a hypodermic needle having one end positioned against said barrel and communicating with the interior thereof;

said other end of said needle being positioned hermetically against the interior of said projecting end of said seal;

means for advancing said barrel in said tube towards said puncturable seal in said container until said needle punctures said puncturable seal;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of said solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container to mix said solvent with said powdered medicament;

means for withdrawing said plunger thereby sucking said mixed medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube;

a flange around the periphery of said puncturable seal;

a flange around said periphery of said opening in said container;

a flange around said end of said hollow tube adjacent said container; and

a metallic clamp engaging said flanges to effect a tight seal therebetween.

18. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube;

a flange around the periphery of said puncturable seal;

a flange around the periphery of said opening in said container;

a flange around the end of said hollow tube adjacent said container; and

a metallic clamp engaging said flanges to effect a tight seal therebetween.

19. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel; and

means for removing said barrel together with said plunger and said needle from said tube wherein the means for advancing and withdrawing the tube comprises a flange positioned at the end of the tube.

20. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel; and

means for removing said barrel together with said plunger and said needle from said tube wherein the means for advancing and withdrawing the plunger in the syringe barrel comprises a flange positioned at the end of a stem on the plunger.

21. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel; and

means for removing said barrel together with said plunger and said needle from said tube wherein the hermetic seal between the barrel and the tube is equipped with a tear tab to facilitate its easy removal when it is desired to move the barrel relative to the tube.

22. A compartmental syringe for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube; and

stop means positioned on said barrel and said tube to limit the movement of said barrel in said tube to a predetermined position.

23. A compartmental syringe disposed for storing and mixing a powdered medicament and a liquid solvent prior to injection comprising:

a container for storage of a predetermined quantity of said powdered medicament;

a puncturable seal of elastomeric material engaging an opening in said container;

a hollow tube projecting from said container and tightly engaging the circumference of said opening and said seal;

a cylindrical syringe barrel slidably positioned within said tube;

a removable hermetic seal between said tube and said syringe barrel;

said syringe barrel having a flanged end and an aperture therethrough;

a puncturable seal covering said aperture;

a metallic clamp tightly engaging said seal against said flanged end of said barrel;

a hypodermic needle positioned within said tube;

a support for said needle positioned within said tube upon the exterior of said flanged end of said barrel and disposed to hold one end of said needle in opposite spaced relation to said aperture in said barrel;

the opposite end of said needle being positioned hermetically against said puncturable seal on said container within said tube;

means for advancing said syringe barrel towards said seal on said container until one end of said needle punctures said seal and the other end punctures said seal over said aperture in said barrel;

a plunger slidably mounted within said barrel;

said barrel containing a predetermined amount of solvent;

means for advancing said plunger in said barrel thereby discharging said solvent through said needle into said container and thereby dissolving said powdered medicament;

means for withdrawing said plunger thereby sucking said dissolved medicament into said barrel;

means for removing said barrel together with said plunger and said needle from said tube wherein the puncturable elastomeric seal on the container is equipped with an opening on its surface disposed to hermetically receive and guide one end of said needle while said needle punctures said seal.