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Biological detection process using polymer-coated electrodes

  • US 4,517,291 A
  • Filed: 08/15/1983
  • Issued: 05/14/1985
  • Est. Priority Date: 08/15/1983
  • Status: Expired due to Term
First Claim
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1. In a method for the amperometric determination of the concentration of a constituent of interest in a biological sample, said method comprising:

  • (1) contacting said constituent with an oxidase enzyme for which the constituent is a substrate, thereby producing a change in the concentration of an electroactive substance in said sample;

    (2) contacting said sample containing said electroactive substance with an inert metal indicator electrode;

    (3) measuring the current flow between said indicator electrode and a counter electrode at a preselected potential difference between said electrodes; and

    (4) relating the current to the concentration of the substrate initially present in the biological sample;

    the improvement comprising;

    using as the inert metal indicator electrode a noble metal having intimately coated thereon a thin film of perfluorosulfonic acid polymer.

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