Hydrophilic denture adhesive

• US 4,518,721 A
• Filed: 04/12/1984
• Issued: 05/21/1985
• Est. Priority Date: 03/26/1982
• Status: Expired due to Term

• Current Assignee: Richardson-Vicks, Inc. (The Procter & Gamble Company)
• Original Assignee: Richardson-Vicks, Inc. (The Procter & Gamble Company)
• Inventors: Schmidt, Nicholas F., Dhabhar, Dadi J.
• Primary Examiner(s): Kight, John
• Assistant Examiner(s): Nutter, Nathan M.
• Application Number:
  US06/599,751
• Time in Patent Office: 404 Days
• Field of Search: 523/120, 523/448, 524/31, 524/35, 524/733, 524/45, 106/35, 106/197 C, 156/328, 433/160, 433/172, 433/180
• US Class Current: 523/120
• CPC Class Codes: A61K 6/35 Preparations for stabilising dentures in the mouth
• CPC Class Codes: C08L 1/286 substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] C08L1/282 takes precedence
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 2666/28 Non-macromolecular organic substances
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C09J 101/286 substituted with acid radicals C09J101/282 takes precedence

Abstract

An improved denture adhesive containing an adhesive polymeric fraction comprising sodium carboxymethylcellulose and poly(ethylene oxide) in a hydrophilic vehicle comprising certain polyethylene glycols and, as an optional component in certain forms of the subject adhesives, glycerin, for enhancing pharmaceutical elegance of the final product.

Claims

1. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 15 to about 55 percent w/w sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 6;

1 to about 1;

6, respectively; and

(b) from about 45 to about 85 percent w/w of a polyethylene glycol fraction comprising one or more polyethylene glycols each having a number average molecular weight of from 200 to 20,000 and said fraction having a viscosity of from about 44 to about 25,600 centipoises at about 60°

C.

2. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 24 to about 50 percent w/w sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2;

1 to about 3.5;

1 respectively; and

(b) from about 50 to about 76 percent w/w of a polyethylene glycol fraction comprising one or more polyethylene glycols each having a number average molecular weight of from about 200 to 20,000 and said fraction having a viscosity of from about 44 to about 2,500 centipoises at about 60°

C.

3. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 32 to about 42.5 percent w/w sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2;

1 to about 3;

1, respectively; and

(b) from about 57.5 to about 68 percent w/w of a polyethylene glycol fraction comprising one or more polyethylene glycols each having a number average molecular weight of from 200 to 20,000 and said fraction having a viscosity of from about 44 to about 2,500 centipoises at about 60°

C.

4. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 15 to about 55 percent w/w sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2;

1 to about 3.5;

1, respectively; and

(b) from about 45 to about 85 percent w/w of a polyethylene glycol fraction comprising one or more polyethylene glycols each having a number average molecular weight of from 200 to 20,000 and said fraction having a viscosity of from about 44 to about 300 centipoises at about 60°

C.

5. The composition of claim 4 wherein said polyethylene glycol fraction comprises a mixture of PEG 400 and PEG 8000 in a weight ratio of from about 9:

1 to about 33;

1, respectively.

6. The composition of claim 4 wherein said polyethylene glycol fraction comprises a mixture of PEG 600 and PEG 8000 in a weight ratio of from about 9:

1 to about 33;

1, respectively.

7. The composition of claim 4 wherein up to about one-half of said polyethylene glycol fraction is substituted with glycerin.

8. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 15 to about 55 percent w/w of sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2;

1 to about 3.5;

1, respectively;

(b) up to about 25 percent w/w of glycerin; and

(c) substantially the remainder of a polyethylene glycol fraction comprising one or more polyethylene glycols each having a number average molecular weight of from 200 to 20,000 and said fraction having a viscosity of from about 44 to about 300 centipoises at about 60°

C.

9. The composition of claim 8 wherein said polyethylene glycol fraction comprises a mixture of PEG 400 and PEG 8000 in a weight ratio of from about 9:

1 to about 33;

1, respectively.

10. The composition of claim 8 wherein said polyethylene glycol fraction comprises a mixture of PEG 600 and PEG 8000 in a weight ratio of from about 9:

1 to about 33;

1, respectively.

11. The composition of claim 8 wherein (b) comprises from about 5 to about 15 percent w/w of said glycerin.

12. The composition of claim 8 wherein (b) comprises about 10 percent w/w of said glycerin.

13. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) from about 24 to about 50 percent w/w of sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2;

1 to about 3.5;

1, respectively;

(b) from about 5 to about 15 percent w/w of glycerin; and

(c) substantially the remainder of a polyethylene glycol fraction comprising a mixture of PEG 400 and PEG 8000 in a weight ratio of from about 9;

1 to about 33;

1 respectively.

14. The composition of claim 13 wherein (a) comprises about 32 percent w/w of sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2:

1 to about 3;

1, respectively.

15. The composition of claim 13 wherein (a) comprises about 42.5 percent w/w of sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of from about 2:

1 to about 3;

1, respectively.

16. A denture adhesive composition consisting essentially of a substantially anhydrous mixture of:

(a) about 32 percent w/w of sodium carboxymethylcellulose and poly(ethylene oxide) homopolymer in a weight ratio of about 3;

1, respectively;

(b) about 10 percent w/w glycerin;

(c) up to about 0.5 percent w/w of flavoring and coloring agents; and

(d) substantially the remainder of a polyethylene glycol fraction comprising a mixture of PEG 400 and PEG 8000 in a weight ratio of from about 9;

1 to about 33;

1 respectively.

17. A denture adhesive composition consisting essentially of:

(a) about 24% w/w of sodium carboxymethylcellulose;

(b) about 8% w/w of poly(ethylene oxide) hompolymer;

(c) about 55.25% w/w of polyethylene glycol 400;

(d) about 2.3% w/w of polyethylene glycol 8000;

(e) about 10% w/w of glycerin; and

(f) about 0.45% w/w of flavoring and coloring agents.

18. A denture adhesive composition consisting essentially of:

(a) about 31.9% w/w of sodium carboxymethylcellulose;

(b) about 10.6% w/w of poly(ethylene oxide) homopolymer;

(c) about 44.4% w/w of polyethylene glycol 600;

(d) about 2.8% w/w of polyethylene glycol 8000;

(e) about 10.0% w/w of glycerin; and

(f) about 0.3% w/w of flavoring and coloring agents.

19. A denture adhesive composition in powder form consisting essentially of:

(a) about 24-30% w/w of sodium carboxymethylcellulose;

(b) about 8-10% w/w of poly(ethylene oxide) homopolymer; and

(c) about 60-68% w/w of polyethylene glycol 8000.