Ion selective membranes for use in ion sensing electrodes
First Claim
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1. A method of producing an ion-sensing electrode from a tube of solid swellable plastic having a proximal end, a distal end, an outer wall and a first lumen, comprising the following steps:
- dissolving an ion-selective material in a solvent which is a swelling agent for said solid swellable plastic;
subsequently soaking at least a portion of said tube in said solvent in which said ion-selective material has been dissolved;
after said soaking step drying said tube until said solvent evaporates; and
after said drying step filling the first lumen of said tube with an electrolyte gel,sealing the distal end of the first lumen of said tube and inserting a first electrode into the first lumen of said tube.
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Abstract
An improved method for producing ion-selective membranes having a desired shape and of a desired plastic, for incorporation in ion-sensing electrodes, and the electrodes incorporating these membranes. This method allows the use of preformed polymeric members having the desired shape to produce ion-selective membranes, allowing simplified production of ion-sensing electrodes, as well as combination ion-sensing and reference electrodes.
136 Citations
21 Claims
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1. A method of producing an ion-sensing electrode from a tube of solid swellable plastic having a proximal end, a distal end, an outer wall and a first lumen, comprising the following steps:
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dissolving an ion-selective material in a solvent which is a swelling agent for said solid swellable plastic; subsequently soaking at least a portion of said tube in said solvent in which said ion-selective material has been dissolved; after said soaking step drying said tube until said solvent evaporates; and after said drying step filling the first lumen of said tube with an electrolyte gel, sealing the distal end of the first lumen of said tube and inserting a first electrode into the first lumen of said tube. - View Dependent Claims (2, 3)
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4. A method for producing an ion-selective membrane of a desired solid swellable plastic, having a desired shape, comprising the ordered steps of:
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dissolving an ion-selective material in a solvent which is also a swelling agent for said desired solid swellable plastic; subsequently soaking a member fabricated of said desired solid swellable plastic and having said desired shape, in said solvent in which said ion selective material has been dissolved; and subsequently removing said solvent from said member. - View Dependent Claims (5, 6, 7, 13, 14, 15)
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8. A method for producing an ion-selective membrane of silicone rubber, having a desired shape, comprising the ordered steps of:
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dissolving an ion selective material comprising nonactin in a solvent comprising methylene chloride which is also a swelling agent for silicone rubber; subsequently soaking a member fabricated of silicone rubber, having said desired shape, in said solvent in which said ion-selective material has been dissolved; and subsequently removing said solvent from said member.
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9. A method for producing an ion-selective membrane of polyurethane, having a desired shape, comprising the ordered steps of:
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dissolving an ion-selective material comprising valinomycin in a solvent comprising acetone which is also a swelling agent for polyurethane; subsequently soaking a member fabricated of polyurethane having said desired shape in said solvent in which said ion-selective material has been dissolved; and subsequently removing said solvent from said member. - View Dependent Claims (11)
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10. A method for producing an ion-selective membrane of polyvinylchloride, having a desired shape, comprising the ordered steps of:
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dissolving an ion-selective material comprising valinomycin in a solvent comprising dipentyl pthalate which is also a swelling agent for polyvinylchloride; subsequently soaking member fabricated of polyvinylchloride having said desired shape, in said solvent in which said ion-selective material has been dissolved; and subsequently removing said solvent from said member.
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12. A method for producing an ion-selective membrane of silicone rubber having a desired shape, comprising the ordered steps of:
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dissolving an ion-selective material comprising methyltricapryl ammonium chloride in a solvent comprising xylene which is also a swelling agent for silicone rubber; subsequently soaking a member fabricated of silicone rubber having said desired shape, in said solvent in which said ion-selective material has been dissolved; and subsequently removing said solvent from said member.
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16. A method for producing an ion-selective membrane of silicone rubber, having a desired shape, comprising the ordered steps of:
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dissolving an ion-selective material comprising tridodecylamine in a solvent comprising dichlorodifluoromethane which is also a swelling agent for silicone rubber; subsequently soaking a member fabricated of silicone rubber, having said desired shape in said solvent in which said ion-selective material has been dissolved; and subsequently removing said solvent from said member.
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17. A method of fabricating a membrane of a desired solid swellable plastic, selected for desired ion and having a desired shape, comprising the steps of:
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selecting a member of said solid, swellable plastic, having said desired shape; dissolving an ion-selective material selective for said desired ion in a solvent which is a swelling agent for said solid swellable plastic; soaking said member in said solvent in which said ion-selective material has been dissolved until said member has swelled; and drying said swelled member until said solvent has evaporated and said member has returned to said desired shape. - View Dependent Claims (18)
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19. A method of fabricating an ion sensing electrode from a tube of solid, swellable plastic having a proximal end, a distal end, an outer wall and a first lumen open to said proximal end, comprising the following steps:
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dissolving a material selective for said desired ion in a solvent which is a swelling agent for said solid swellable plastic; soaking at least a portion of said tube in said solvent in which said ion-selective material has been dissolved, until said tube swells; drying said swelled tube until said solvent evaporates and said swelled tube returns to its original dimensions; and after said drying step, filling the first lumen of said tube with an electrolyte gel and inserting a first electrode into the first lumen of said tube. - View Dependent Claims (20, 21)
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Specification