Aqueous antimicrobial ophthalmic solutions
First Claim
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1. An aqueous ophthalmic contact lens solution comprising:
- from about 0.00001 to about 3.0 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said compound having the formula ##STR3## wherein X=a pharmaceutically acceptable anion;
an effective amount of NaCl to provide isotonicity to said solution; and
an effective amount of buffer to provide said solution with an ophthalmically acceptable pH.
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Abstract
This invention relates to ophthalmic compositions which comprise quaternary ammonium salt having the formula ##STR1## wherein X=a pharmaceutically acceptable anion, such compositions providing aqueous disinfecting solutions for contact lenses as well as a preserved ocular compositions including contact lens treating solutions comfort drop solutions, preserved saline solutions, ointments and other ocular medicaments.
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Citations
25 Claims
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1. An aqueous ophthalmic contact lens solution comprising:
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from about 0.00001 to about 3.0 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said compound having the formula ##STR3## wherein X=a pharmaceutically acceptable anion;
an effective amount of NaCl to provide isotonicity to said solution; andan effective amount of buffer to provide said solution with an ophthalmically acceptable pH. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An isotonic contact lens disinfecting solution comprising from about 0.001 to about 0.01 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said quaternary ammonium compound having the formula ##STR4## wherein X=a pharmaceutically acceptable anion;
- an effective amount of NaCl to provide isotonicity to said solution;
an effective amount of a buffer to provide said solution with an ophthalmically acceptable pH. - View Dependent Claims (18, 19, 20)
- an effective amount of NaCl to provide isotonicity to said solution;
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21. A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising:
adding to said solution from about 0.00001% to about 3.0% by weight/volume of a quaternary ammonium salt as an antimicrobial agent having a molecular weight in the range of about 3,000 to about 14,000, said quaternary ammonium salt having the formula ##STR5## wherein X=a pharmaceutically acceptable anion. - View Dependent Claims (22, 23, 24, 25)
Specification