Device for storing and dispensing drug doses

• US 4,526,474 A
• Filed: 06/19/1984
• Issued: 07/02/1985
• Est. Priority Date: 06/25/1983
• Status: Expired due to Term

• Current Assignee: Medical Technology Systems Inc (Omnicell Inc)
• Original Assignee: Udo Simon
• Inventors: Simon, Udo
• Primary Examiner(s): Roskoski, Bernard
• Application Number:
  US06/622,099
• Time in Patent Office: 378 Days
• Field of Search: 368/10, 368/107, 368/109, 368/89, 206/534, 116/308
• US Class Current: 368/10
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61J 7/04 Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• CPC Class Codes: A61J 7/0436 resulting from removing a drug from, or opening, a container
• CPC Class Codes: A61J 7/0481 working on a schedule basis

Abstract

A device is described for storing, and periodically announcing the time for removal of, drug doses in pill, tablet or capsule form. A patient is warned at regular intervals to remove a drug dose from a blister pack serving as drug container.

An electronic timer system associated with the blister pack activates periodically a signal emitter which emits a preferably acoustic signal. Optionally an optical signal emitter can also be installed in the warning ystem. The system comprises an electrically activatable input which receives a starting pulse at the time when a first drug dose is to be removed from the blister pack. The starting pulse is generated by rupturing, through removal of a drug dose from a blister pocket, an electric pulse lead which extends across the blister pocket in the rupturable closing foil of the latter and which is connected to the starting pulse input of the timer in the warning system.

Claims

1. A device for the storage and the periodical dispensing of a drug, comprising a drug container, an electronic timer system, associated with said drug container, and comprising a signal emitter being activated, at adjustable time intervals, and starting pulse input means connected with said signal emitter and being adapted for electric activation and for feeding of an electric starting pulse thereinto,

said drug dose body containing means comprising a first foil containing a series of blister pockets arranged in at least one row and adapted for each of said pockets receiving a drug dose body therein, and at least one backing foil closing off said pockets and adapted for being ruptured in a rupturable foil area opposite each of said pockets, upon pressure being exercized in the area of a drug dose body on that side, of said first foil, from which said blister pockets project,

at least one electric pulse lead extending across each of said rupturable areas of said at least one second foil and being connected with said pulse input means and being connected with said starting pulse input means of said timer system, said electric pulse lead being rupturable together with said rupturable foil area;

said signal emitter and electric pulse lead being so arranged as to introduce an electric pulse from said lead via said starting pulse input means into said signal emitter at least at the first time rupturing of said electric pulse lead.

2. The device of claim 1, wherein said signal emitter is adapted for emitting an acoustic signal.

3. The device of claim 1, wherein said signal emitter is an optical signal.

4. The device of claim 1, wherein said timer system is an integral part of said drug container, and wherein said device further comprises electric building units being supported directly on said second foil.

5. The device of claim 4, wherein said electric building units comprise an integrated electric circuit.

6. The device of claim 1, further comprising separable connecting means for connecting said electric timer system detachably with said drug container.

7. The device of claim 1, wherein said electric pulse lead is integrated in said second foil.

8. The device of claim 1, wherein said electric pulse lead extends via several up to all of the blisters of the drug container.

9. The device of claim 1, wherein said drug container comprises blisters being filled with drug dose bodies of at least two types of drugs of different strength and different effective duration, and said electronic timer system comprises a corresponding number of at least two memory registers and the same corresponding number of starting pulse input means, and a corresponding electric pulse lead, each of said blisters being connected via a pulse lead with the corresponding pulse input means pertaining to the respective type of drug present in such blister.

10. The device of claim 9, wherein said timer system comprises a time-indicating means adapted for indicating the contents of that respective memory register which has been activated and recalled.

11. The device of claim 1, wherein said timer system comprises setting means for the input of register contents and a lockable cover for said setting means.

12. The device of claim 1, wherein said timer comprises setting means and setting pulse input means associated therewith, said setting pulse entry means being adapted for being shut off after programming.

13. The device of claim 1, wherein said electric pulse lead extends across said rupturable areas in an undulating configuration.

14. The device of claim 1, wherein said electric pulse lead extends across said rupturable areas in a zigzag configuration.

15. The device of claim 12, wherein said setting means comprise interruptable setting pulse leads, and said setting pulse input means are adaptable for being activated via said last-mentioned leads, said last-mentioned leads being applied on said second foil of said drug container so as to correspond with said electric pulse leads.

16. The device of claim 9, wherein said timer system comprises first setting pulse input means adapted for the input of a first drug dose consumption time, and second setting pulse input means adapted for the input of the time period for a consumption cycle.

17. The device of claim 12, wherein said setting pulse input means are in a pre-determined arrangement, and said timer system further comprises a perforated template adapted for being placed on said second foil in a preset, position marked thereon, said template being adapted for covering said arrangement of setting pulse input means in such a manner that, when said template is in said preset position on said second foil, only those setting pulse input means which are destined to be ruptured, are uncovered because they register with a perforation of said template and can thus be ruptured individually.

18. The device of claim 12, wherein said timer system comprises a programming punch and perforating pins protruding from one face of said punch, said perforating pins being disposed in a pin arrangement corresponding to the location of certain pre-selected setting pulse input means in said predetermined input means arrangement, said punch thus being adapted for simultaneously rupturing said certain setting pulse input means.

19. The device of claim 1, wherein said timer system comprises as a building unit, an integrated electrical circuit and an electronic sensor circuit, said sensor circuit being connected with said electric pulse leads on the input side.

20. The device of claim 19, wherein said sensor circuit is adapted for acting as a differentiator.

21. The device of claim 20, wherein said sensor circuit comprises, for each electric pulse lead present, two flip-flops connected in series and constituting a two-bit shifting register, and two exclusive-OR gates, each of said gates being connected on the output side to a different one of said flip-flops, the output of each gate being connected with a starting pulse input means of said integrated electrical circuit.

22. The device of claim 1, wherein the states of the electric pulse leads are checked only during timely separated short call pulses, in order to save electric energy.

23. The device of claim 22, wherein said timer system comprises first setting pulse input means, and calling of the electric pulse leads takes place after the activation of at least one of the first setting pulse input means.

24. The device of claim 1, wherein said timer system comprises a common starting pulse lead, as well as, connected in parallel with each section of an electric pulse lead extending across a blister pocket, a separate resistor, and an analogdigital converter type circuit adapted for determining the changes in total resistance, said converter type circuit having an input to which said common starting pulse lead is connected.

25. The device of claim 24, wherein each resistor is deposited on said second foil by the thick layer depositing method.

26. The device of claim 24, wherein each of said resistors has a different resistance value, and the dispensing interval period depends on the amount of resistance increase occurring when the corresponding electric pulse lead suction, connected with the respective resistor is ruptured.

27. The device of claim 1, wherein said timer system comprises a plurality of starting pulse inputs adapted for being recalled by at least one analog/digital converter, and, connected with each of the starting pulse inputs, a resistor chain, each of said starting pulse inputs also being connected with a section of said electric pulse lead extending across a blister pocket.

28. The device of claim 9, wherein said timer system comprises an integrated electric circuit and a second signal emitter connected with the output side of said integrated electric circuit.

29. The device of claim 28, wherein said second signal emitter is adapted for emitting optical signals.

30. The device of claim 1, wherein said signal emitter comprises a piezoelectric loudspeaker, adapted for emitting differently modulated sound signals.

31. The device of claim 1, wherein said signal emitter comprises a piezoelectric loudspeaker, adapted for emitting sounds of different frequencies.

32. The device of claim 1, wherein said timer system comprises an additional optical indicating means adapted for being activated automatically after a pre-selected period of time, whenever, after activation of the signal emitter, no drug dose body has been dispensed from the drug container.

33. The device of claim 1, wherein said timer system comprises an additional optical indicating means connected in series at the outlet side of said signal emitter and being automatically activatable whenever the signal emitter is activated after a periodically re-occurring period of time.