Diagnostic method and apparatus for clamping blood glucose concentration

• US 4,526,568 A
• Filed: 09/29/1982
• Issued: 07/02/1985
• Est. Priority Date: 09/29/1982
• Status: Expired due to Fees

• Current Assignee: Miles Laboratories, Inc. (Bayer AG)
• Original Assignee: Miles Laboratories, Inc. (Bayer AG)
• Inventors: Hough, David L., Clemens, A. H.
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Beaucage, Gregory
• Application Number:
  US06/426,983
• Time in Patent Office: 1,007 Days
• Field of Search: 604/4, 604/28, 604/50, 604/27, 604/30, 604/31, 604/51, 604/52, 604/56, 604/65-67, 128/DIG. 13
• US Class Current: 604/4.01
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A diagnostic apparatus and method for clamping the blood glucose concentration of a subject at any one of a plurality of levels. A desired clamping level (BC) is selected and the value of the present blood glucose concentration, corrected to fit a least squares regression lines (GY) in the bloodstream of the subject is periodically determined. Dextrose is introduced into the bloodstream of the subject at a rate (DR) derived in accordance with ##EQU1## wherein: DR=dextrose infusion rate for clamp (mg/min)

WT=body weight (kg)

BC=desired clamp level (mg %)

GY=present blood glucose level, corrected to fit a least squares regression line (mg %)

M=slope of the least squares regression line fit for the last five glucose values

KS=constant to allow adjustment for differences in metabolism ##EQU2## (Glucose utilization in mg/kg/min).

Claims

1. A diagnostic method for clamping the blood glucose concentration of a subject at any one of a plurality of levels, comprising the steps of:

selecting a desired clamping level (BC);

periodically determining the value of the present blood glucose concentration (GY) in the bloodstream of the subject; and

introducing dextrose into the bloodstream of the subject at a rate (DR) derived in accordance with ##EQU7## wherein;

DR=dextrose infusion rate for clamp (mg/min)

WT=body weight (kg)

BC=desired clamp level (mg %)

GY=present blood glucose level, corrected to fit a least squares regression line (mg %)

M=slope of the least squares regression line fit for the last five glucose values

KS=constant to allow adjustment for differences in metabolism ##EQU8## (Glucose utilization in mg/kg/min).

2. The method according to claim 1, further comprising the step of introducing insulin into the bloodstream of the subject at a rate

3. The method according to claim 2, further comprising introducing insulin into the bloodstream at a plurality of selected different fixed rates (IR) for a normoglycemic clamp level (BC) and determining the steady state value of the dextrose infusion rate (DR) for each insulin infusion rate.