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Diagnostic method and apparatus for clamping blood glucose concentration

  • US 4,526,568 A
  • Filed: 09/29/1982
  • Issued: 07/02/1985
  • Est. Priority Date: 09/29/1982
  • Status: Expired due to Fees
First Claim
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1. A diagnostic method for clamping the blood glucose concentration of a subject at any one of a plurality of levels, comprising the steps of:

  • selecting a desired clamping level (BC);

    periodically determining the value of the present blood glucose concentration (GY) in the bloodstream of the subject; and

    introducing dextrose into the bloodstream of the subject at a rate (DR) derived in accordance with ##EQU7## wherein;

    DR=dextrose infusion rate for clamp (mg/min)WT=body weight (kg)BC=desired clamp level (mg %)GY=present blood glucose level, corrected to fit a least squares regression line (mg %)M=slope of the least squares regression line fit for the last five glucose valuesKS=constant to allow adjustment for differences in metabolism ##EQU8## (Glucose utilization in mg/kg/min).

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