Portable device for infusing insulin on the basis of glycemic measurements

• US 4,526,569 A
• Filed: 11/03/1982
• Issued: 07/02/1985
• Est. Priority Date: 11/04/1981
• Status: Expired due to Fees

• Current Assignee: Tecnomed SRL
• Original Assignee: Tecnomed SRL
• Inventors: Bernardi, Luigi
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Kaechele, Karen
• Application Number:
  US06/438,785
• Time in Patent Office: 972 Days
• Field of Search: 128/DIG. 3, 128/DIG. 13, 128/632, 128/635, 604/4-6, 604/27-31, 604/43, 604/65-67, 604/269, 427/2, 427/4, 427/251, 210/498, 210/506-510, 210/434, 210/433.2, 210/927, 210/96.2
• US Class Current: 604/6.09
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The invention relates to a device made by a concentric dual lumen catheter, a pump, a small hemofilter, a glucose sensor which, by means of a microinfusion pump with a stepping motor controlled by a microprocessor can, through another concentric dual lumen catheter, inject insulin or glucose into the blood stream depending on glycemic levels.

Claims

1. A portable device having a circuit for blood drawing and re-immission, said circuit comprising:

(a) means for drawing blood from a patient into the circuit;

(b) a filter connected to said means for drawing blood, said filter being permeable only to the water and microsolutes of the drawn blood such that said water and microsolutes pass through the filter whereas other constituents of the drawn blood including cells, proteins and other macromolecules do not pass through the filter;

(c) a glucose sensor connected to said filter for receiving said water and microsolutes;

(d) means for connecting said glucose sensor to said filter directly such that no substance other than said water and microsolutes flows between said filter and said glucose sensor;

(e) a microprocessor connected to said glucose sensor which resonds to the glucose levels measured by said sensor by sending control signals; and

(f) means connected to said microprocessor for infusing glucose and or insulin into the patient in response to said control signals received from the microprocessor.

2. The portable device of claim 1, wherein said filter is a hemofilter comprising hollow fibers.

3. The portable device of claim 1, further comprising means for infusing the cells, proteins and other macromolecules of the drawn blood back into the patient.

4. The portable device of claim 3, further comprising means for adjusting the hematocrit ratio of the cells, proteins, and other macromolecules before they are infused back into the patient.

5. The portable device of claim 4, wherein said means for adjusting said hematocrit ratio comprise a concentric dual lumen catheter with one lumen containing said cells, proteins, and other macromolecules and the other containing an amount of physiological solution required to provide an appropriate hematocrit value.

6. The portable device of claim 1, wherein said means for infusing insulin and/or glucose into the patient comprise a stepping motor, a pump, and a valve, said stepping motor acting on pulses received from said microprocessor to make the pump turn clockwise or counterclockwise to operate the valve to permit infusion of glucose or insulin into the patient.

7. The portable device of claim 6, wherein said means for infusing insulin and/or glucose into the patient comprise a "Y" shaped junction formed by the confluence of insulin and glucose tubing with the upper legs of the "Y" being respectively formed by an insulin carrying tube and a glucose carrying tube, and the lower leg of the "Y" being formed to carry either glucose or insulin into the patient, said valve comprising a plastic membrane fixed to the bottom of the intersection formed by said insulin carrying tube and said glucose carrying tube, said plastic membrane operating upon rotation of said pump to respectively open or close said insulin carrying tube or said glucose carrying tube.

8. The portable device of claim 5, further comprising means for reinfusing into the patient said water and microsolutes which have passed through said filter.

9. The portable device of claim 8, wherein said means for reinfusing into the patient said water and microsolutes comprise the concentric dual lumen catheter which forms part of said means for adjusting said hematocrit ratio.

10. The portable device of claim 9, wherein said means for infusing glucose and/or insulin into the patient comprise the concentric dual lumen catheter which forms part of said means for adjusting said hematocrit ratio.