Cardioplegic controlling and regulating system

• US 4,529,397 A
• Filed: 07/24/1983
• Issued: 07/16/1985
• Est. Priority Date: 02/09/1982
• Status: Expired due to Fees

• Current Assignee: Sartorius Gmbh
• Original Assignee: Sartorius Gmbh
• Inventors: Knothe, Erich, Pradel, Gunter, Kohn, Heinz G., Hennemuth, Kurt
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/460,483
• Time in Patent Office: 723 Days
• Field of Search: 604/4, 604/27-29, 604/6, 604/53, 604/56, 604/83, 128/DIG. 3, 210/927, 210/650, 210/651
• US Class Current: 604/6.09
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3646 Expelling the residual body fluid after use, e.g. back to the body
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir

Abstract

A cardioplegic controlling and regulating device for the dosed perfusion of cardioplegic perfusion solution in open-heart surgery has a storage container for receiving the cardioplegic solution, which container is part of a scale and can be connected to the heart over a tubular conduit. A pressure-controlled dosing pump which acts on the tubular conduit and cooperates with a second, reversible pump which is constructed as an exhaust pump and is selectively operable synchronously or asynchronously within controllable tolerance limits with the first dosing pump during the perfusion and sustaining of the perfusion. An ultrafilter for the mixture of blood and cardioplegic solution removed from the patient'"'"'s heart is located in a removal line. An outlet for the blood separated form the ultrafilter is connected by a conduit to a blood storage container and the permeate or filtrate outlet of which ends in a filtrate line or in a filtrate collector vessel. The ultrafilter is located in a by-pass line to a blood storage container so that the patient'"'"'s blood mixed with cardioplegic solution can be prepared to a hemoconcentrate after the perfusion has been completed. In the same manner, other blood removed by suction from the patient during the operation can be prepared by this by-pass line and the ultrafilter. Another pressure-controlled dosing pump sustains the first dosing pump and is connected to it in parallel.

Claims

1. In a cardioplegic controlling and regulating system for cardioplegic perfusion solution, including a reservoir means for the cardioplegic solution, a first tubular conduit operatively coupled to the reservoir means and adapted to deliver cardioplegic solution to a patient'"'"'s heart, at least one pressure-controlled dosing pump adapted to force cardioplegic solution through the first conduit, an exhaust conduit adapted to remove blood and cardioplegic solution from the patient'"'"'s heart, and a blood collection vessel means, the exhaust conduit being operatively coupled to the blood collection vessel means, the improvement comprising a second pump which is constructed as an exhaust pump and is adapted to remove the blood and cardioplegic solution from the heart, the second pump being adapted to selectively operate synchronously or assynchronously within predetermined limits with the at least one dosing pump, an ultrafilter means operatively coupled to the exhaust conduit and adapted to separate the blood and the cardioplegic solution, a third conduit operatively coupled at one end there of the ultrafilter means and at the other end thereof to the blood collection vessel means, a filtration conduit operatively coupled at one end thereof to the permeate or filtrate outlet of the ultrafilter means and at the other end thereof operatively coupled to a filtrate receiving collection vessel.

2. The system of claim 1 wherein a third perfusion pump supplies a quantity of cardioplegic solution, the third perfusion pump being operatively connected in parallel to the at least one pressure-controlled dosing pump through another perfusion line.

3. The system of claim 1 wherein the speed of the second pump can be controlled and regulated within a range of -20% to +100% of the speed of the at least one pressure-controlled dosing pump.

4. The system according to claim 1 wherein pressure sensors are operatively connected to the first tubular conduit and are connected to a pressure regulating device, the pressure regulating device being operatively connected to the pressure-controlled dosing pump as well as to the exhaust pump to control the perfusion.

5. The system according to claim 1 wherein the second pump is a reversible pump operatively coupled to a fluid line forming a blood perfusate line having one end that is operatively coupled to the blood collection vessel means and another end operatively coupled to the exhaust conduit, the exhaust conduit being valved by a control valve so that when the control valve is closed, blood and cardioplegic solution removed by the second pump bypasses the ultrafilter means.

6. The system according to claim 1 further comprising a pressure sensor adapted to provide an electrical feedback signal to a pressure regulating device which controls the second pump, thereby preventing air from being exhausted from the heart area.

7. The system according to claim 5 further comprising an irrigation line having a valve, the irrigation line being operatively coupled between said blood perfusate line and an irrigation solution storage vessel.

8. The system according to claim 5 further comprising a hematocrit sensing means operatively coupled to said third conduit for measuring the hemoconcentration of the mixture of blood and cardioplegic solution after the mixture has been passed a plurality of times through the ultrafilter means in a closed circular line formed by the exhaust conduit, the blood perfusate line, and the third conduit.

9. The system according to claim 8 wherein the filtrate receiving collection vessel is mounted on a scale for monitoring the filtrate collected in the filtrate receiving collection vessel.

10. The system according to claim 8 wherein the hematocrit sensing means is an optical sensor.

11. The system according to claim 8, wherein the hematocrit sensing means is an electrical conductivity meter.

12. The system according to claim 8 wherein the hematocrit sensing means is an electrical capacitance sensor.

13. The system according to claim 1 wherein the reservoir means for the cardioplegic solution is disposed on a weighing scale.