Process for preparing synthetic absorbable poly(esteramides)
First Claim
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1. A process for making a body absorbable polymeric material having a plurality of units of the general formula:
- ##STR3## in which R1 is hydrogen or methyl;
R3 and R5 are identical or different and are groups selected from the class consisting of linear and branched alkylene, alkylene having 1 or 2 nonadjacent catenary oxygen or sulfur atoms, alkenylene, cycloalkylene and arylene;
said groups having up to 25 carbon atoms in the cyclic compounds and from 2 to 25 carbon atoms in the non-cyclic compounds;
R2 and R4 are hydrogen or alkyl having 1 to 4 carbon atoms or R2 and R4 together are linear or branched alkylene having one to four carbons forming with N--R3 --N a heterocyclic group having 5 or 6 ring atoms; and
a and b are independently zero or onesaid process comprising the steps of;
reacting at least one diamine with lactic or glycolic acid to form at least one diamidediol; and
reacting said at least one diamidediol with a bischloroformate or a compound selected from the group consisting of dicarboxylic acids, methyl and ethyl esters of dicarboxylic acids, diacidchlorides, and anhydrides of a dicarboxylic acid to provide said body adsorbable polymeric material.
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Abstract
A body absorbable polymeric material for implantation which is a condensation product of reacting a diamine with lactic or glycolic acid to form a diamidediol which is then reacted with a bischloroformate or a compound selected from the group consisting of dicarboxylic acids, methyl and ethyl esters of dicarboxylic acids, diacidchlorides, and anhydrides of a dicarboxylic acid.
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6 Claims
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1. A process for making a body absorbable polymeric material having a plurality of units of the general formula:
- ##STR3## in which R1 is hydrogen or methyl;
R3 and R5 are identical or different and are groups selected from the class consisting of linear and branched alkylene, alkylene having 1 or 2 nonadjacent catenary oxygen or sulfur atoms, alkenylene, cycloalkylene and arylene;
said groups having up to 25 carbon atoms in the cyclic compounds and from 2 to 25 carbon atoms in the non-cyclic compounds;R2 and R4 are hydrogen or alkyl having 1 to 4 carbon atoms or R2 and R4 together are linear or branched alkylene having one to four carbons forming with N--R3 --N a heterocyclic group having 5 or 6 ring atoms; and a and b are independently zero or one said process comprising the steps of;
reacting at least one diamine with lactic or glycolic acid to form at least one diamidediol; and
reacting said at least one diamidediol with a bischloroformate or a compound selected from the group consisting of dicarboxylic acids, methyl and ethyl esters of dicarboxylic acids, diacidchlorides, and anhydrides of a dicarboxylic acid to provide said body adsorbable polymeric material. - View Dependent Claims (2, 3, 4, 5, 6)
- ##STR3## in which R1 is hydrogen or methyl;
Specification