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Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents

  • US 4,530,840 A
  • Filed: 07/29/1982
  • Issued: 07/23/1985
  • Est. Priority Date: 07/29/1982
  • Status: Expired due to Term
First Claim
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1. An anti-inflammatory agent containing microparticle composition prepared by a process, comprising:

  • (a) dissolving or dispersing an anti-inflammatory agent selected from the group consisting of a prednisolone, a triamicinolone, a dexamethasone and a β

    -methasone in a solvent selected from the group consisting of acetone, a halogenated hydrocarbon, an aromatic hydrocarbon. a halogenated aromatic hydracarbon, a cyclic ether, an alcohol and water and dissolving a biocompatible and biodegradable wall forming material in said solvent;

    (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium of water, toluene, xylene, a synthetic oil or a natural oil;

    (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and

    (d) extracting the remainder of the solvent from said microparticles.

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