Centrifugal plasmapheresis device

• US 4,531,932 A
• Filed: 11/22/1982
• Issued: 07/30/1985
• Est. Priority Date: 11/27/1981
• Status: Expired due to Term

• Current Assignee: Dideco SPA
• Original Assignee: Dideco SPA
• Inventors: Luppi, Libero, Calari, Alessandro
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Kartchner, Gene B.
• Application Number:
  US06/443,975
• Time in Patent Office: 981 Days
• Field of Search: 494/17-18, 494/13-14, 494/21, 494/23, 210/927, 604/4-6, 128/DIG. 3
• US Class Current: 604/6.05
• CPC Class Codes: B04B 15/02 for cooling, heating, or heat insulating
• CPC Class Codes: B04B 2005/045 having annular separation channels
• CPC Class Codes: B04B 2013/006 Interface detection or monitoring of separated components
• CPC Class Codes: B04B 5/0428 with flexible receptacles

Abstract

The device comprises a single needle circuit having lines for admitting whole blood drawn from a patient to a continuously rotating rotor, re-introducing red cells and collecting plasma, the lines being respectively connected to the three outlets of a coupling static block rigidly attached to the rotor, two photocell-lightsource assemblies being further provided for automatically cyclically switching over the blood pick up and red cells introduction steps in the device steady state condition of operation.

Claims

1. A centrifugation plasmapheresis device comprising:

a continuously rotating rotor for re-introducing red cells and collecting plasma in a provided vessel;

a rotating hollow shaft supporting said rotating rotor;

a single needle circuit having lines for admitting the whole blood drawn from a person to said continuously rotating rotor;

a rotating block rigidly attached to said rotating rotor and having outlets arranged in radial symmetry;

a static block supported by said rotating block and having outlets connected to said lines of said single needle circuit;

at least two slots symmetrically located and open at the top which are arranged in said rotating rotor;

said slots having constantly varying radii with respect to the rotation axis of said rotating rotor;

at least two pockets housed in said two slots wherein centrifugation separation of red cells from plasma is to take place;

said two pockets being formed from a collapsible flexible material;

two tubes one of each of said tubes connected to one end of each of said pockets which is inserted in the smallest radius region of said slots;

a small tube arranged along the entire circumference of the rotating rotor;

two diametrically opposed fittings each connected with an other end of said pockets which is inserted in the largest radius region and with said small tube, said fittings defining two semicircular portions of said small tube;

two opposed radial channels extending substantially from a centerline of each of said semicircles of said small tube which are defined by said fittings and connected to said outlets of said rotating block;

automatically cyclically switching means for picking up the whole blood in a first step and for red cells re-introduction in a second step during steady state operation;

attemperating temperature means arranged in said rotating rotor for preventing the blood from cooling during its residence in said rotating rotor with attendant viscosity increase which adversely effect the separation process.

2. A centrifugation plasmapheresis device as claimed in claim 1, wherein the device comprises four rotating rings engaging four fixed electric brushes to ensure electric continuity between said rotating rotor and a machine static portion, said rotating rings being rigidly attached to the hollow shaft.

3. A centrifugation plasmapheresis device as claimed in claim 1 wherein said attemperating temperature means comprise a plurality of heat regulating plugs for attemperating the temperature of a rotating rotor portion having a good heat conductor material, said heat regulating plugs being arranged in said portion at equal distance along said rotating rotor circumference.

4. A centrifugation plasmapheresis device as claimed in claim 1, wherein it comprises leads powering said heat regulating plugs, said leads being inserted through said hollow shaft and connected to one ring of the four rotating rings.

5. A centrifugation plasmapheresis device as claimed in claim 1 wherein the device comprises a sensor element regulating the temperature of said heat regulating plugs which is connected electrically to the other three rotating rings.

6. A centrifugation plasmapheresis device comprising:

a continuously rotating rotor for re-introducing red cells and collecting plasma in a provided vessel;

a rotating hollow shaft supporting said rotating rotor;

a single needle circuit having lines for admitting the whole blood drawn from a person to said continuously rotating rotor;

a rotating block rigidly attached to said rotating rotor and having outlets arranged in radial symmetry;

a static block supported by said rotating block and having outlets connected to said lines of said single needle circuit;

at least two slots symmetrically located and open at the top which are arranged in said rotating rotor;

said slots having constantly varying radii with respect to the rotation axis of said rotating rotor;

at least two pockets housed in said two slots wherein centrifugation separation of red cells from plasma is to take place;

said two pockets being formed from a collapsible flexible material;

two tubes one of each of said tubes connected to one end of each of said pockets which is inserted in the smallest radius region of said slots;

a small tube arranged along the entire circumference of the rotating rotor;

two diametrically opposed fittings each connected with an other end of said pockets which is inserted in the largest radius region and with said small tube, said fittings defining two semicircular portions of said small tube;

two opposed radial channels extending substantially from a centerline of each of said semicircles of said small tube which are defined by said fittings and connected to said outlets of said rotating block;

automatically cyclically switching means for picking up the whole blood in a first step and for red cells re-introduction in a second step during steady state operation;

a plurality of rotating rings rigidly attached to said hollow shaft;

a plurality of fixed electric brushes engaging said rotating rings to ensure electric continuity between said rotating rotor and a machine static portion;

a plurality of heat regulating plugs for attemperating the temperature of a rotating rotor portion having a good heat conductor material;

said heat regulating plugs being arranged at equal distances apart along said rotating rotor circumference;

leads powering said heat regulating plugs;

said leads being inserted through said hollow shaft and connected to one ring of the four rotating rings;

a sensor element regulating the temperature of said plugs which is connected electrically to the other three rotating rings.

7. A centrifugation plasmapheresis device as claimed in claim 6, wherein said automatically cyclically switching means comprise at least two photocells with respective light sources respectively overlying and underlying said rotating rotor, said photocells being connected to at least a peristaltic pumps arranged in said single needle circuit.

8. A centrifugation plasmapheresis device as claimed in claim 7, wherein said photocells are arranged at a distance from the rotation axis corresponding to that of each of two through-going holes provided at the bottom of one of the slots in the proximities of the ends thereof, so as to sense the movement past said holes of the red cell plasma and consequently control the switching over of first and second steps.

9. A centrifugation plasmapheresis device as claimed in claim 6 wherein said single needle circuit comprises a scale to sense the weight of the plasma vessel upon emptying of the same during the operation of re-introduction step for switching over from said re-introduction step to a pick up step.