Renoprotective treatments employing vasodilator compounds
First Claim
1. A method of treating renal damage or failure in a host in need of treatment comprising administering to said host an effective amount for treating renal failure or damage, a vasodilator having postsynaptic alpha-adrenoceptor blocking activity and having antihyperlipidemic characteristics which lower the lipid levels in the bloodstream of the host, said vasodilator being selected from a group consisting of endralazine, trimazosin, minoxidil, diazoxide, doxazosin, triodazosin, phentolamine hydrochloride, phenoxybenzamine hydrochloride, benextramine, indoramine, and yohimbine.
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Abstract
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower cholesterol levels and prevent renal failure or damage. These substances are administered alone or in combination with other substances useful in the treatment of hyperlipidemia such as phenoxyacetic acid derivatives. Suitable vasodilators include: hydralazine hydrochloride and functionally similar agents such as endralazine, trimazosin, minoxidil, and diazoxide; prazosin hydrochloride and functionally similar agents such as doxazosin, triodazosin, phentolamine hydrochloride, phenoxybenzamine hydrochloride, benextramine, indoramine, and yohimbine; clonidine HCl and functionally similar agents such as guanabenz, guanfacine, lofexidine, and UK No. 14,304; labetalol and other combined alpha and beta blocking agents such as prizidolol and peroxidil.
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Citations
8 Claims
- 1. A method of treating renal damage or failure in a host in need of treatment comprising administering to said host an effective amount for treating renal failure or damage, a vasodilator having postsynaptic alpha-adrenoceptor blocking activity and having antihyperlipidemic characteristics which lower the lipid levels in the bloodstream of the host, said vasodilator being selected from a group consisting of endralazine, trimazosin, minoxidil, diazoxide, doxazosin, triodazosin, phentolamine hydrochloride, phenoxybenzamine hydrochloride, benextramine, indoramine, and yohimbine.
Specification