System for automatic feedback-controlled administration of drugs
First Claim
1. An adaptive control system for administering a drug to a subject responsive to a drug/subject system model, comprising:
- (a) means for sensing at least one physiological parameter of said subject and for converting said at least one parameter into a corresponding response signal;
(b) preset means for establishing a preset drug order signal;
(c) means for administering said drug to said subject in response to an actuating signal; and
(d) a control loop for providing said actuating signal to said means for administering, said control loop including;
(i) comparator means for accepting first and second input signals and producing an error signal representing the difference therebetween, said comparator means being connected to said preset means for accepting said order signal as a first input thereto;
(ii) response signal processing means connected to said sensing means for processing said response signal and for providing said processed response signal as a second input of said comparator means;
(iii) means for sampling said response signals and rates at which drugs are administered by said means for administering;
(iv) means for determining values for said drug/subject system model as a function of said sampled signals and rates and producing control signal information in accordance therewith;
(v) adaptive controller means for receiving said error signal from said comparator means and said control signal information from said means for determining, said adaptive controller means translating said error signal into an actuating signal for application to said administering means in accordance with said values for said drug/subject system model defined by said control signal to optimally minimize said error signal.
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Abstract
A system for automatic feedback controlled administration of drugs (SAFCAD) is disclosed for the control of administration of drugs responsive to real-time processed physiological or pharmacological signals. Control apparatus implemented by analog, digital, or optimal-adaptive digital means is described using various combinations of proportional, integral and derivative control loop processes. A preferred digital embodiment uses optimal-adaptive, proportional-integral control which includes on-line physiological system modeling and control loop parameter tuning for the administration of anesthetics such as thiopental.
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Citations
31 Claims
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1. An adaptive control system for administering a drug to a subject responsive to a drug/subject system model, comprising:
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(a) means for sensing at least one physiological parameter of said subject and for converting said at least one parameter into a corresponding response signal; (b) preset means for establishing a preset drug order signal; (c) means for administering said drug to said subject in response to an actuating signal; and (d) a control loop for providing said actuating signal to said means for administering, said control loop including; (i) comparator means for accepting first and second input signals and producing an error signal representing the difference therebetween, said comparator means being connected to said preset means for accepting said order signal as a first input thereto; (ii) response signal processing means connected to said sensing means for processing said response signal and for providing said processed response signal as a second input of said comparator means; (iii) means for sampling said response signals and rates at which drugs are administered by said means for administering; (iv) means for determining values for said drug/subject system model as a function of said sampled signals and rates and producing control signal information in accordance therewith; (v) adaptive controller means for receiving said error signal from said comparator means and said control signal information from said means for determining, said adaptive controller means translating said error signal into an actuating signal for application to said administering means in accordance with said values for said drug/subject system model defined by said control signal to optimally minimize said error signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A control system for administering a drug to a subject comprising:
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means for establishing a preset drug order signal; means for sensing a physiological parameter from a said subject and producing a response signal corresponding to said parameter sensed; means for translating said response signal into an averaged signal representing a weighted average of said physiological parameter sensed; means for administering said drug to said subject in response to an actuating signal; means for comparing said preset drug order signal and said averaged signal and obtaining an error signal corresponding to a difference therebetween; first means for processing a first portion of said error signal according to an integration function to obtain a first signal; second means for processing a second portion of said error signal according to a proportional control function to obtain a second signal; and means for combining said first and second signals into an actuating signal and applying said actuating signal to said means for administering said drug to said subject. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification