Oxygen sensor for rapid blood gas analysis

• US 4,533,456 A
• Filed: 04/05/1984
• Issued: 08/06/1985
• Est. Priority Date: 04/05/1984
• Status: Expired due to Term

• Current Assignee: Critikon Co. LLC (GE Aerospace)
• Original Assignee: Critikon Co.
• Inventors: Janata, Jiri, Kratochvil, Jiri
• Primary Examiner(s): Tung, T.
• Application Number:
  US06/597,001
• Time in Patent Office: 488 Days
• Field of Search: 204/1 T, 204/1 P, 204/402, 204/415, 204/409
• US Class Current: 204/415
• CPC Class Codes: G01N 33/4915 using flow cells flow cytometry G01N15/14
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

In systems for rapid sequential analysis of fluid samples, such as blood samples, an electrochemical sensor is capable of equally rapid, sequential sample response by avoiding the need for equilibration during the measuring phase, and by substantially replacing the electrolyte acceptor for each sample. The sensor is made up of a pair of electrodes, an electrolyte acceptor, and a gas permeable membrane separating the electrolyte from the sample stream. Samples are passed rapidly by the membrane, and at the end of each such pass, the electrodes are polarized for a certain period, the flow of electrical current is measured, and the electrolyte is flushed and replaced by new electrolyte. This membrane material can be hydrophobic and also hydrophilic in nature.

Claims

1. In a system for analysis of partial pressures of gases in blood, an oxygen sensor comprising:

(a) an oxygen permeable membrane to which blood samples are periodically exposed for a predetermined time period;

(b) an electroylte acceptor for oxygen which passes through said membrane;

(c) an anode electrode and a cathode electrode, which both are immersed in said electroyte; and

the improvement which comprises

(d) means for substantially replacing the electrolyte in said sensor prior to each presentation of respective samples to the other side of said membrane;

(e) control means automatically operating a switch means for establishing an open circuit condition between said electrodes during replacement of said electrolyte and during and for a first predetermined time after presentation of each of said samples, and for polarizing said electrodes at a predetermined voltage for a second predetermined time; and

(f) means for measuring current between said electodes at the end of said second predetermined time.

2. A system as described in claim 1 wherein said first predetermined time is approximatley 13 sec., and said second predetermined time is approximately 10 sec.

3. A system as described in claim 2 wherein said anode is silver/silver chloride and said cathode is platinum.