Detection of lung cancer using breath luminescence

• US 4,534,360 A
• Filed: 05/27/1983
• Issued: 08/13/1985
• Est. Priority Date: 05/27/1983
• Status: Expired due to Term

• Current Assignee: Williams, Martin D.
• Original Assignee: Williams, Martin D.
• Inventors: Williams, Martin D.
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/498,762
• Time in Patent Office: 809 Days
• Field of Search: 128/716, 128/719, 128/664, 128/665, 128/666, 128/730, 128/206.29, 128/207.11, 422/84
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0813 Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

Subjects may be screened for possible lung cancer by a breath luminescence measurement apparatus and technique. The apparatus comprises a photon counter with special provisions for the exclusion of light from sources other than the patient'"'"'s breath. A special light exclusion mask is used together with tortuous breath exhaust passages to exclude external light. A gauze plug in the breathing tube excludes light emitted by the patient'"'"'s mouth tissues. Special adapters are provided so that the photon counter can be used for endoscopic measurement of internal tissue luminescence and for sample luminescence measurements.

Claims

1. A method of screening for lung cancer in a human patient comprising the steps of:

measuring the quantity of light spontaneously emitted by the patient'"'"'s breath; and

comparing the quantity of light so measured with a preestablished standard for persons of the same age as the patient who are free of lung cancer, whereby if the quantity of light emitted by the patient'"'"'s breath is substantially below the preestablished standard, the patient is considered a candidate for further diagnostic testing.

2. A method according to claim 1 in which the measuring step is carried out by means of an electronic light detector and in which light from sources other than the patient'"'"'s breath is excluded from the light detector.

3. A method according to claim 2 in which the electronic light detector is a photon counter.

4. A method according to claim 1 in which the patient breathes into a chamber, light from all sources other than the patient'"'"'s breath is excluded from the chamber, and the measuring step is carried out by measuring the quantity of light emitted by the patient'"'"'s breath in said chamber.

5. A method according to claim 4 in which the measurement takes place while the patient exhales through the chamber, and the patient'"'"'s breath exits from the chamber through a tortuous path.

6. A method according to claim 4 in which the patient breathes into the chamber through a tube and in which the patient is fitted with a light-proof mask extending from the tube to the patient'"'"'s face, said mask having an upper opening fitting about the patient'"'"'s face at approximately the level of the patient'"'"'s nose, a lower opening, fitting about the patient'"'"'s neck, and a front opening receiving the tube, said mask being fitted about the patient'"'"'s face and neck and about the tube with sufficient tightness to prevent the entry of light from external sources into the tube.

7. A method according to claim 1 in which the patient breathes into a chamber, and light from all sources other than the patient'"'"'s breath is excluded from the chamber, and the measuring step is carried out by photon counting.