Device for releasing active ingredient, insertable in a system of parenteral administering the ingredient

• US 4,534,757 A
• Filed: 06/03/1983
• Issued: 08/13/1985
• Est. Priority Date: 06/14/1982
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Geller, Leo
• Primary Examiner(s): Shine, W. J.
• Application Number:
  US06/500,744
• Time in Patent Office: 802 Days
• Field of Search: 604/82, 604/83, 604/84, 604/85, 604/86, 604/126, 604/246, 604/251, 604/252, 604/253, 604/254, 604/257, 604/406, 604/416
• US Class Current: 604/85
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162

Abstract

A device for releasing active ingredient into a liquid flow passing through a system for parenteral application of the ingredient comprises a receptacle composed of two half shells. The receptacle is subdivided by a ribbed aluminium foil into two chambers and has an inlet at its upper end and an outlet at its lower end. The two chambers have vent means at their upper ends. One of the chambers contains two overflows a first one of which empties into the outlet while the second one empties into the other chamber. In the latter chamber there is present a further overflow which also empties into the outlet, as well as a plate-shaped carrier charged with the active ingredient to be released. The liquid flows from the inlet via the first chamber and the second overflow therein into the other chamber and from there upwardly past a carrier charged with active ingredient, and onward via a third overflow in the other chamber into the outlet. In a second flow path, part of the liquid flows directly from the inlet through the first chamber and via the first overflow therein into the outlet.

This device permits a very uniform release of active agent and is of simple construction and correspondingly it can be manufactured in an inexpensive manner.

Claims

1. A device for releasing active ingredient, which device is insertable in the liquid flow line of a system for the parenteral application of the ingredient, and comprises a receptacle having an inlet and outlet for a liquid flow passing therethrough, and ingredient-releasing means, lodged in the receptacle, for releasing active ingredient into the said liquid flow, said receptacle further comprising in its interior two liquid flow paths leading from the inlet to the outlet thereof, one of which paths comprises a section through which the liquid passes in a direction substantially opposite to a general direction in which the receptacle is passed by the liquid, and an ingredient-releasing unit being present in the said path section of opposite liquid flow.

2. The device of claim 1, wherein said receptacle comprises two communicating chambers and, in each of said chambers, an overflow emptying into said outlet, said inlet leading into the upper part of a first one of said chambers while said ingredient-releasing unit is located in the second one of said chambers.

3. The device of claim 2, wherein said receptacle further comprises a further overflow by way of which said two chambers communicate with one another and which further overflow empties into the lower part of said second chamber.

4. The device of claim 2, wherein said receptacle comprises two half shells.

5. The device of claim 4, wherein each of said half shells is an integral piece of artificial plastic resin material.

6. The device of claim 4, wherein said receptacle comprises a separating wall having an edge clamped in between said two half shells and subdividing said receptacle into said two chambers.

7. The device of claim 1, wherein said receptacle comprises in the upper end zone thereof, containing said inlet, vent means and a filter associated with said vent means and being pervious essentially for gases only.

8. The device of claim 1, wherein said ingredientreleasing unit is a plate-shaped carrier being charged with the active ingredient.

9. The device of claim 8, wherein said receptacle has an outer wall and holding means protruding inwardly from said outer wall and being adapted for holding said plateshaped carrier in position in the interior of said receptacle.

10. The device of claim 9, wherein said holding means comprise vanes or ribs.