Method and apparatus for determining the viability and survival of sensori-neutral elements within the inner ear

• US 4,535,785 A
• Filed: 09/23/1982
• Issued: 08/20/1985
• Est. Priority Date: 09/23/1982
• Status: Expired due to Fees

• Current Assignee: 3M Company
• Original Assignee: 3M Company
• Inventors: van den Honert, Christopher, Stypulkowski, Paul H.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Falk, Steven
• Application Number:
  US06/421,992
• Time in Patent Office: 1,062 Days
• Field of Search: 128/746, 128/731-733, 73/585, 179/12
• US Class Current: 600/559
• CPC Class Codes: A61B 5/12 Audiometering
• CPC Class Codes: A61F 11/04 Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense, e.g. through the touch sense electronic stimulation of auditory nerves A61N1/36036
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

A method and apparatus for diagnosing the extent of survival of the peripheral sensori-neural elements within the inner ear of a patient by stimulating the patient with one or more pair of electrical stimulus signals having a known amplitude and inter-signal delay, and by measuring the electrical activity within the nervous system of the patient which results from these stimulus signals and comparing the activity which results from the second stimulus signal with the activity which results from the first stimulus signal.

Claims

1. A method of diagnosing the extent of survival of the peripheral sensori-neural elements with a patient, comprising the steps of:

stimulating the inner ear of the patient with a first electrical stimulus signal and a second electrical stimulus signal having a first predetermined delay with respect to said first electrical stimulus signal;

measuring the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal and said second electrical stimulus signal having a first predetermined delays

then stimulating the inner ear of the patient with said first electrical stimulus signal and said second electrical stimsulus signal having a second predetermined delay with respect to said first electrical stimulus signal;

measuring the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal and said second electrical stimulus signal having a second predetermined delay; and

comparing the electrical activity within the nervous system of the patient which results from said first and second electrical stimulus signals with said first predetermined delay with the electrical activity within the nervous system of the patient which results from said first and second electrical stimulus signal with said second predetermined delay.

2. The according to claim 1 wherein said stimulation of the inner ear with a first or a second electrical stimulus signal comprises implanting an active electrode adjacent to or within the inner ear of the patient, generating a constant current pulse having a predetermined amplitude and a predetermined duration, and conveying said constant current pulse to said active electrode thereby stimulating the inner ear.

3. The method according to claim 1 further comprising normalizing the electrical activity within the nervous system of the patient which results from the second electrical stimulus signal by the electrical activity within the nervous system which results from the first electrical stimulus signal, and determining the normalized electrical activity which results from said second stimulus signal as a function of the inter signal delay.

4. The method according to claim 2 further comprising placing a return electrode in electrical contact with the skin of the patient.

5. The method according to claim 2 further comprising implanting a return electrode adjacent to or within the inner ear but remote from the active electrode.

6. The method according to claim 1 wherein said measuring of electrical activity with the nervous system comprises implanting a first electrode adjacent to or within the auditory nerve and placing a second electrode in electrical contact with the skin of the patient.

7. A method as in claim 1 wherein said predetermined delays are varied to occur on either side of the absolute refractory.

8. An apparatus for determining the viability of peripheral sensori-neural elements within a cochlea of a patient, comprising:

means for stimulating the inner ear of the patient with a first electrical stimulus signal and a second electrical stimulus signal having a first predetermined delay with respect to said first electrical stimulus signal;

means for measuring the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal and said second electrical stimulus signal having a first predetermined delay;

means for stimulating the inner ear of the patient with said first electrical stimulus signal and said second electrical stimulus signal having a second predetermined delay with respect to said first electrical stimulus signal;

means for measuring the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal and said second electrical stimulus signal having a second predetermined delay; and

means for comparing the electrical activity within the nervous system of the patient which results from said first and second electrical stimulus signal with said first predetermined delay with the electrical activity within the nervous system of the patient which results from said first and second electrical stimulus signal with said second predetermined delay.

9. An apparatus as claimed in claim 8 wherein said means for stimulating the inner ear comprises a first electrode adapted to be implanted adjacent the round window of the patient'"'"'s inner ear;

means for generating a first electrical pulse having a predetermined amplitude and a predetermined duration;

means for generating a second electrical pulse having a predetermined amplitude, a predetermined duration, and a predetermined delay with respect to the first electrical siganl; and

means for conveying said electrical pulses to said first electrode.

10. An apparatus as claimed in claim 8 wherein said means for measuring the electrical activity which occurs as a result of said electrical stimulus signals comprises a first electrode implanted adjacent to or within the auditory nerve and a second electrode placed in electrical contact with the skin of the patient.

11. An apparatus as claimed in claim 8 further comprising means for normalizing the electrical activity resulting from said second electrical signal by the electrical activity resulting from said first electrical signal, and means for determining the normalized electrical activity resulting from said second electrical signal as a function of the inter signal delay.

12. An apparatus as claimed in claim 8 further comprising a second electrode adapted to be placed cutaneously on the patient.

13. An apparatus as claimed in claim 9 further comprising a second electrode also adapted to be implanted adjacent the round window of the inner ear but remotely from said first electrode and coupled to said means for conveying.

14. An apparatus as in claim 8 wherein said predetermined delays are varied to occur on either side of the absolute refractory.

15. A method of diagnosing the extent of survival of the peripheral sensori-neural elements within a patient, comprising the steps of:

stimulating the inner ear of the patient with a first electrical stimulus signal;

measuring the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal;

stimulating the inner ear of the patient with a second electrical stimulus signal and a third electrical stimulus signal having a first predetermined delay with respect to said second electrical stimulus signal;

measuring the electrical activity within the nervous system of the patient which results from said second electrical stimulus signal and said third electrical stimulus signal;

subtracting the measured electrical activity within the nervous system which results from said first electrical stimulus signal from the measured electrical activity within the nervous system of the patient which results from said second and third electrical stimulus signals;

stimulating the inner ear of the patient with a fourth electrical stimulus signal and a fifth electrical stimulus signal having a second predetermined delay with respect to said fourth electrical stimulus signal;

measuring the electrical activity within the nervous system of the patient which results from said fourth electrical stimulus signal and said fifth electrical stimulus signal;

subtracting the electrical activity within the nervous system of the patient which results from said first electrical stimulus signal from the measured electrical activity within the nervous system of the patient which results from said fourth and fifth electrical stimulus signals; and

comparing the electrical activity within the nervous system of the patient resulting from said first subtraction with the electrical activity within the nervous system of the patient which results from said second subtraction.