Self-driven pump assembly and method of operation

• US 4,539,004 A
• Filed: 04/23/1984
• Issued: 09/03/1985
• Est. Priority Date: 09/22/1982
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Eckenhoff, James B., Peery, John R., Place, Virgil A.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Lester, Michelle N.
• Application Number:
  US06/602,937
• Time in Patent Office: 498 Days
• Field of Search: 604/56, 604/131, 604/132, 604/151, 604/153, 604/892, 604/893, 604/896
• US Class Current: 604/131
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons

Abstract

A pump assembly particularly useful as an infusor for parenteral administration of a small amount of a therapeutically active substance for a prolonged period of time at a substantially constant rate comprising a fluid imbibing pump mounted within a receptacle into which actuating fluid may be charged. The active agent is dispensed from the pump after the pump is exposed to the fluid. Means to vary or stop the pump by obdurating all or a portion of the exterior surface of the pump can also be provided. Variation in flow rates can also be obtained by changing the composition of the actuating fluid.

Claims

1. A pump assembly for delivering small amounts of a fluid for a prolonged period of time comprising, in combination:

(a) fluid impermeable container means provided with outlet means;

(b) fluid imbibing pump means mounted within said container means the outlet of said pump means being in fluid communicating relationship to the outlet in said container means, the interior of said container means and the exterior of said pump means defining therebetween a fluid receiving volume sufficient, when charged with actuating fluid to actuate said pump; and

(c) at least a portion of said fluid impermeable container means being formed from a flexible, collapsible, impermeable material which portion has a collapse capacity at least equal to the discharge capacity of said fluid imbibing pump, whereby imbition of fluid contained within the fluid receiving volume during actuation of said pump means will not create a vacuum of said fluid imbibing pump means.

2. The pump assembly of claim 1 wherein said flexible collapsible wall portion is formed from an elastic material expansible from (i) an initial condition in close fitting relationship to the exterior of said fluid imbibing pump;

to (ii) an expanded condition having a volumetric capacity at least equal to the volume of fluid to be discharged from said fluid imbibing pump means.

3. The pump assembly of claim 1 wherein at least a portion of said flexible, collapsible, impermeable material is provided with self-sealing means through which actuating fluid may be introduced between said material and said fluid imbibing pump means.

4. The pump assembly of claim 2 wherein at least a portion of said elastic material is provided with self sealing means through which actuating fluid may be introduced between said elastic material and said fluid imbibing pump means.