In vivo therapeutic apheresis using lipid vesicles
First Claim
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1. A method of removing an immunologically reactive compound from the blood of a living mammal, which comprises;
- introducing into the blood in a living mammal an immunological homolog of said compound, bound to the surface of a lipid vesicle, in the blood, whereby the bound homolog and the compound mix and react to form a complex; and
separating the resulting complex from the blood plasma.
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Abstract
Disclosure is made of a means and method for removing immunologically reactive compounds from the blood of living mammals. The method of the invention comprises reacting the compound with an immunological homolog of the compound, bound to the surface of a lipid vesicle and thereafter separating the resulting complex from the blood plasma of the mammal.
72 Citations
1 Claim
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1. A method of removing an immunologically reactive compound from the blood of a living mammal, which comprises;
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introducing into the blood in a living mammal an immunological homolog of said compound, bound to the surface of a lipid vesicle, in the blood, whereby the bound homolog and the compound mix and react to form a complex; and separating the resulting complex from the blood plasma.
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Specification
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Current AssigneeApplied Immune Sciences, Inc. (Sanofi )
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Original AssigneeApplied Immune Sciences, Inc. (Sanofi )
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InventorsMarten, James F.
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Primary Examiner(s)Rosenbaum, C. Fred
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Assistant Examiner(s)Samaras, Harrie S.
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Application NumberUS06/468,158Time in Patent Office931 DaysField of Search604/4-6, 604/28, 436/829, 436/536, 436/538, 436/541US Class Current604/28CPC Class CodesA61M 1/3687 Chemical treatment A61M1/36...A61M 2202/0014 removed from the bodyA61M 2202/0447 GlycoproteinsA61M 2202/0456 Lipoprotein
