Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
First Claim
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1. An anti-inflammatory agent containing a microparticle composition prepared by a process, comprising:
- (a) dissolving or dispersing an apti-inflammatory agent excluding corticosteroid anti-inflammatory agents and selected from the group consisting of enzymes, hormones, phenylbutazones, salicylates, steroids and sulfonamides in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent;
(b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium;
(c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and
(d) extracting the remainder of the solvent from said microparticles.
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Abstract
An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.
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12 Claims
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1. An anti-inflammatory agent containing a microparticle composition prepared by a process, comprising:
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(a) dissolving or dispersing an apti-inflammatory agent excluding corticosteroid anti-inflammatory agents and selected from the group consisting of enzymes, hormones, phenylbutazones, salicylates, steroids and sulfonamides in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microparticles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification