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Self-normed brain state monitoring

  • US 4,545,388 A
  • Filed: 06/09/1983
  • Issued: 10/08/1985
  • Est. Priority Date: 06/09/1983
  • Status: Expired due to Fees
First Claim
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1. A machine-implemented method for monitoring the occurrence and ascribed medical significance of changes in a patient undergoing a medical procedure relative to a prior state of the patient at a time selected for medical relevance to the planned procedure after administration of anesthesia, comprising:

  • electrically measuring brain functions of the patient which are selected for medical relevance to a medical procedure which the patient is to undergo, at said time at which the patient is in a state selected for medical relevance to the procedure, said selected state being after administration of anesthesia;

    processing the measurements to produce a self-norm comprising, for each brain function, a respective statistically and medically significant mean measurement and a respective statistically and medically significant standard deviation or variance measurement;

    electrically measuring the same brain functions of the same patient during the said procedure, at each of a sequence of time intervals selected for medical relevance to the procedure;

    testing each new set of measurements for statistically and medically significant change from the self-norm;

    converting each significant change to a dimensionless probability of significant deviation and combining at least two of the said probabilities through vector addition into a single vector-form indication of said medically significant change; and

    producing a tangible indication of the vector-form indication of the significant change, said tangible indication conveying information both as to the occurrence of a change and as to the ascribed medical significance of the change itself and the persistence of the change.

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