Analytical element having improved spreading zone and method of use
First Claim
1. A dry element for the analysis or transport of an aqueous liquid, said element comprising an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material, and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound having at least 12 carbon atoms therein, which compound is present in said zone in an amount of at least about 2 weight percent, based on the dry weight of said blush polymer.
2 Assignments
0 Petitions
Accused Products
Abstract
A dry element capable of use for the analysis or transport of liquids comprises an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound comprising at least 12 carbon atoms therein. This compound is present in the porous zone in an amount of at least about 2 weight percent, based on the dry weight of the blush polymer. The porous zone of this element has improved cohesive strength which improves its resistance to abrasion. The element can be used to determine an analyte in an aqueous liquid, such as biological fluids.
18 Citations
20 Claims
- 1. A dry element for the analysis or transport of an aqueous liquid, said element comprising an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material, and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound having at least 12 carbon atoms therein, which compound is present in said zone in an amount of at least about 2 weight percent, based on the dry weight of said blush polymer.
-
5. A dry analytical element for determination of an analyte in an aqueous liquid, said element comprising:
-
a support having thereon an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material, and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound having at least 12 carbon atoms therein, which compound is present in said zone in an amount of at least about 2 weight percent, based on the dry weight of said blush polymer; and said element containing an interactive composition for an analyte to be determined. - View Dependent Claims (6, 7, 8, 9, 10, 11)
-
8. The element of claim 6 wherein said quaternary ammonium compound is a heterocyclic amine represented by the structure (Ib) wherein R1, R2 and R3, taken together with the nitrogen atom, complete a 5 to 20-membered quaternary heterocyclic ring.
-
9. The element of claim 6 wherein said quaternary ammonium compound is selected from the group consisting of:
- ##STR12## wherein n is 8, 25 or 41;
##STR13## wherein R'"'"' is alkyl of 12, 14 or 16 carbon atoms; and
##STR14## wherein R" is alkyl of 8 to 18 carbon atoms, x and y are independently integers of 2 to 50.
- ##STR12## wherein n is 8, 25 or 41;
-
10. The element of claim 9 wherein said quaternary ammonium compound is ##STR15## wherein n is 8 or 25.
-
11. The element of claim 5 wherein said quaternary ammonium compound is present in said porous zone in an amount of from about 8 to about 30 weight percent, based on the dry weight of said blush polymer.
-
-
12. A dry multizone analytical element for determination of an analyte in an aqueous liquid, said element comprising
a support having thereon, in order and in fluid contact, a reagent zone containing at least one component of said composition, and an isotropically porous spreading zone which comprises a blush polymer having dispersed therein a particulate material, and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound which is present in said zone in an amount of at least about 2 weight percent, based on the dry weight of said blush polymer; -
wherein said quaternary ammonium compound is represented by the structures (Ia and b);
##STR16## wherein represents a single or double bond;
R1, R2, R3 and R4 independently alkyl of 1 to 30 carbon atoms,
space="preserve" listing-type="equation">--alkylene-oxy--.sub.n --Hwherein said alkylene comprises 2 to 6 carbon atoms and n is an integer of 1 to 50;
aryl of 6 to 14 carbon atoms, cycloalkyl of 5 to 20 carbon atoms, alkaryl of 7 to 30 carbon atoms, or a fluorocarbon group of 1 to 30 carbon atoms;
provided that R1, R2, R3 and R4 together comprise at least 12 carbon atoms;
orR1 and R2, taken together with the nitrogen atom, form a quaternary heterocyclic ring and R3 and R4 are as defined above and comprise together at least 12 carbon atoms;
orR1, R2 and R3, taken together with the nitrogen atom, form a quaternary heterocyclic ring and R4 is as defined above and comprises at least 12 carbon atoms; and X- is a monovalent anion; and said element containing an interactive composition for an analyte to be determined. - View Dependent Claims (13, 14, 15)
-
-
16. A method for the determination of an analyte in an aqueous liquid, said method comprising the steps of:
-
A. physically contacting a sample of said liquid together with an interactive composition for said analyte and a dry analytical element to provide a detectable change, said element comprising an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material, and a nonopolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound having at least 12 carbon atoms therein, which compound is present in said zone in an amount of at least about 2 weight percent, based on the dry weight of said blush polymer; and B. measuring said detectable change. - View Dependent Claims (17, 18, 19, 20)
-
Specification