Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization

• US 4,551,132 A
• Filed: 12/01/1982
• Issued: 11/05/1985
• Est. Priority Date: 02/18/1980
• Status: Expired due to Fees

• Current Assignee: Emil Pasztor, Jozsef Nagy, Katalin Pallosy Nee Becker, Laszlo Lazar
• Original Assignee: Emil Pasztor, Jozsef Nagy, Katalin Pallosy Nee Becker, Laszlo Lazar
• Inventors: Nagy, Jozsef, Lazar, Laszlo, Pasztor, Emil, Pallosy nee Becker, Katalin
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Vinyard, Sherri E.
• Application Number:
  US06/445,690
• Time in Patent Office: 1,070 Days
• Field of Search: 604/96-103, 604/52-53, 128/325, 128/656-658
• US Class Current: 604/507
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61K 49/0442 Polymeric X-ray contrast-enhancing agent comprising a halogenated group
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08G 77/14 containing silicon bound to oxygen-containing groups C08G77/045 takes precedence
• CPC Class Codes: C08G 77/16 to hydroxyl groups
• CPC Class Codes: C08G 77/18 to alkoxy or aryloxy groups
• CPC Class Codes: C08G 77/20 containing silicon bound to unsaturated aliphatic groups C08G77/045 takes precedence
• CPC Class Codes: C08G 77/26 nitrogen-containing groups
• CPC Class Codes: C08G 77/70 Siloxanes defined by use of the MDTQ nomenclature
• CPC Class Codes: C08K 5/54 Silicon-containing compounds C08K5/0091 takes precedence
• CPC Class Codes: C08L 2666/44 Silicon-containing compounds
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10S 528/901 Room temperature curable silicon-containing polymer

Abstract

A silicon rubber embolization agent used in general as well as cerebral vascular surgery having a component A which is composed of: a linear, low viscosity polysiloxane selected from the group consisting of dialkyl, alkylaryl, alkenylalkyl, and diarylpolysiloxanes having reactive functional groups selected from the group consisting of hydroxyl, acyloxyl, alkoxyl and amino; a low viscosity cyclic dialkylpolysiloxane having the formula [R₂ SiO]₄, wherein R is alkyl; a pharmaceutically acceptable iodo-containing organosilicium; or a non-metallic, organic X-ray contrast material, and a component B which is a therapeutically acceptable cross-linking catalyst.

Claims

1. In a method of embolization wherein an occlusion is formed in the vascular system by the vulcanization of an embolization agent in situ the improvement comprising said embolization agent being a silicone rubber component having reactive functional groups selected from the groups consisting of hydroxyl, acyloxyl, alkoxyl, and amino;

a cyclic dialkyl-polysiloxane and a pharmaceutically acceptable iodo-containing organosilicium or non-metallic organic X-ray contrast material, and a component B comprising an effective amount of a therapeutically acceptable cross-linking catalyst.