Patient controlled medication infusion system

• US 4,551,133 A
• Filed: 04/16/1984
• Issued: 11/05/1985
• Est. Priority Date: 04/16/1984
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: American Hospital Supply Corp. (Baxter International Inc.)
• Inventors: Coble, Stephen J., Zegers de Beyl, Rene H.
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/600,663
• Time in Patent Office: 568 Days
• Field of Search: 604/65-67, 604/246, 128/DIG. 12, 128/DIG. 13
• US Class Current: 604/66
• CPC Class Codes: A61M 2005/1405 Patient controlled analgesia [PCA]
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A medication infusion system which includes an infusion line for introducing medication to a peripheral vein of a patient. The infusion system includes a pump for delivering the medication and a pressure transducer within the infusion line for converting sensed fluid pressure waves to electrical signals. An amplifier is provided within the system for increasing the strength of the electrical signal. A gain control amplifier is electrically connected within the system for maintaining the electrical signal at a predetermined amplitude regardless of input variations. A tracking filter is provided within the system to provide an electrical signal representative of the patient'"'"'s respiration rate over a preselected full clinical respiration rate range. A microprocessor is provided within the system for deriving from the electrical signal a control signal for controlling the operation of the pump. The microprocessor includes the ability to determine the presence or absence of the electrical signal representative of the patient'"'"'s respiration rate, a comparator for comparing the rate signal with a preselected respiration rate and a storage capability for storing the rates and preselected rate values. The system further includes a motor control for providing a signal to the pump for actuating the pump in preselected increments when directed by the microprocessor.

Claims

1. A medication infusion system comprising:

an infusion line for introducing medication to a peripheral vein of a patient;

pump means along the infusion line for delivering medication through the infusion to the peripheral vein of the patient;

pressure transducer means in fluid wave communication with medication in the infusion line for converting sensed fluid pressure waves to electrical signals;

amplifier means electrically connected to the pressure transducer means for increasing the strength of the electrical signal;

gain controlled amplifier means electrically connected to the amplifier means for maintaining the electrical signal at a predetermined amplitude regardless of the input amplitude variations of the electrical signal;

tracking filter means electrically connected to the gain controlled amplifier means for filtering the electrical signal provided by the pressure transducer means through the gain controlled amplifier means to provide an electrical signal representative of the patient'"'"'s respiration rate over a preselected full clinical respiration rate range;

a computer means operatively connected to the tracking filter means for deriving from the electrical signal a control signal for controlling the operation of the pump means which is operatively connected to the computer means, the computer means comprising;

means for determining the presence of an electrical signal representative of the patient'"'"'s respiration rate;

clock means for converting the electrical signal to a rate signal representative of the patient'"'"'s respiration rate;

first comparing means for comparing the rate signal with a preselected respiration rate;

storage means for storing each rate signal; and

incremental motor control means for providing a signal to the pump means for actuating the pump means in preselected increments when the rate signal is present and is greater than the preselected respiration rate and for providing a signal to the pump means to stop such pump means when no electrical signal is detected.

2. A medication infusion system as recited in claim 1 wherein the tracking filter means comprises a band pass filter electrically connected to the gain controlled amplifier means, a zero crossing detector electrically connected to the band pass filter, and a phase lock loop means for driving the band pass filter to provide an electrical signal representative of the patient'"'"'s respiration rate.

3. A medication infusion system as recited in claim 2 wherein the phase lock loop means comprises a zero comparator electrically connected to the zero crossing detector, a low pass filter electrically connected to the zero comparator, a buffer amplifier electrically connected to the low pass filter, a voltage controlled oscillator electrically connected to the amplifier and the band pass filter, and a locked oscillator electrically connected to the voltage controlled oscillator and zero comparator.

4. A medication infusion system as recited in claim 1 further comprising a low pass filter electrically connected to the amplifier means and gain controlled amplifier means for filtering electrical noise from the signal.

5. A medication infusion system as recited in claim 1 wherein the means for determining the presence of an electrical signal comprises gain averaging means for averaging the gain applied to the signal by the gain controlled amplifier means over a preselected period of time and second comparing means for comparing the average gain applied to the initial gain which provides an indication of the presence of an electrical signal when the average gain applied is greater than the initial gain and provides an indication of a loss of electrical signal when the average gain applied is less than the initial gain.

6. A medication infusion system as recited in claim 5 further comprising alarm means operatively connected to the computer means for providing a signal when such second comparing means detects the average gain applied is greater than the initial gain.

7. A medication infusion system as recited in claim 5 wherein the means for determining the presence of an electrical signal further comprises:

the storage means storing an initial static fluid pressure in the infusion line;

averaging means for averaging static fluid pressure over a preselected period of time; and

third comparing means for comparing the average static fluid pressure with the initial static fluid pressure which provides an indication of the presence of an electrical signal when the average static fluid pressure is less than the initial static fluid pressure and provides an indication of a loss of electrical signal when the average static fluid pressure is greater than the initial static fluid pressure.

8. A medication infusion system as recited in claim 7 further comprising alarm means operatively connected to the computer means for providing a signal when such third comparing means detects the average static fluid pressure is greater than the initial static fluid pressure.

9. A medication infusion system as recited in claim 1 wherein the means for determining the presence of an electrical signal comprises:

the storage means storing an initial static fluid pressure in the infusion line;

averaging means for averaging static fluid pressure over a preselected period of time; and

third comparing means for comparing the average static fluid pressure with the initial static fluid pressure which provides an indication of the presence of an electrical signal when the average static fluid pressure is less than the initial static fluid pressure and provides an indication of a loss of electrical signal when the average static fluid pressure is greater than the initial static fluid pressure.

10. A medication infusion system as recited in claim 1 wherein the tracking filter means provides an electrical signal representative of the patient'"'"'s respiration rate and heart rate over a preselected clinical range.

11. A medical infusion system as recited in claim 10 wherein the computer means further comprises:

means for converting the electrical signal representative of the patient'"'"'s heart rate to a heart rate signal;

fourth comparing means for comparing the heart rate signal to a preselected heart rate; and

the incremental motor control means further provides a signal to the pump means to stop the pump means when the heart rate signal is less than the preselected heart rate.

12. A medication infusion system as recited in claim 11 further comprising alarm means operatively connected to the computer means for providing a signal when such fourth comparing means detects the detected heart rate is less than the preselected heart rate.

13. A medication infusion system as recited in claim 1 further comprising alarm means operatively connected to the computer means for signaling when an absence of signal is detected by such computer means.

14. A medication infusion system as recited in claim 1 further comprising alarm means operatively connected to the computer means for providing a signal when such first comparing means detects that the rate signal is less than the preselected respiration rate.

15. A medication infusion system as recited in claim 1 wherein the computer means is programmed to derive a control signal for controlling the operation of the pump by the steps of:

comparing the electrical signal to determine if present;

if an electrical signal is absent, providing a control signal to the pump means for stopping the pump means from delivering medication;

if the electrical signal is present, then comparing the electrical signal with a preselected respiration rate;

determining whether the electrical signal is below the preselected rate;

if the electrical signal is below the preselected rate, then providing a control signal to the pump means for stopping the pump means from delivering medication;

if the electrical signal is greater than the preselected rate, then providing a control signal to the pump means for providing a predetermined dosage of medication.

16. A medication infusion system as recited in claim 15 wherein the computer means is further programmed to derive a control signal for controlling the operation of the pump by the steps of:

fifth comparing means comparing the time between the last incremental delivery of medication and the current time and comparing such time differential to a preselected time differential;

if such time differential is less than such preselected time differential, then delaying the control signal to the pump means until such time differential equals the preselected time differential;

if such time differential is greater than the preselected time differential, then providing a control signal to the pump means for delivering an aliquot of medication to the patient.

17. A medication infusion system comprising:

an infusion line for introducing medication to a peripheral vein of a patient;

pump means along the infusion line for delivering medication through the infusion line to the peripheral vein of the patient;

pressure transducer means in fluid wave communication with medication in the infusion line for converting sensed fluid pressure waves to electrical signals;

filter means electrically connected to the pressure transducer means for filtering the electrical signal provided by the pressure transducer means to provide an electrical signal representative of the patient'"'"'s respiration rate;

an analog to digital converter means operatively connected to the filter means for producing digital monitor signals which are representative of the patient'"'"'s respiration rate;

a computer means operatively connected to the analog to digital converter means for deriving from the digital monitor signals a control signal for controlling the operation of the pump means which is operatively connected to the computer means, the computer means comprising;

means for determining the presence or absence of a signal;

clock means for converting the digital monitor signal to a rate signal representative of the patient'"'"'s respiration rate;

first comparing means for comparing the digital monitor signal with a preselected respiration rate;

second comparing means for comparing the digital monitor signal with the unfiltered electrical signal;

storage means for storing each digital monitor signal;

third comparing means for comparing the digital monitor signal with an earlier digital monitor signal stored in such storage means; and

incremental motor control means for providing a signal to the pump means for actuating the pump means in preselected increments.

18. A medication infusion system as recited in claim 17 wherein the filter means provides an electrical signal representative of the patient'"'"'s respiratory rate and heart rate;

the analog to digital converter means produces a first digital monitor signal representative of the patient'"'"'s respiration rate and a second digital monitor signal representative of the patient'"'"'s heart rate; and

the computer means further comprises;

second clock means for converting the second digital monitor signal to a rate signal representative of the patient'"'"'s heart rate;

fourth comparing means for comparing the second digital monitor signal with a preselected heart rate;

fifth comparing means for comparing the second digital monitor signal with the unfiltered electrical signal;

second storage for storing such second digital monitor signal; and

sixth comparing means for comparing the second digital monitor signal with an earlier second digital monitor signal stored in such second storage means.