Reference electrode assembly

• US 4,552,625 A
• Filed: 12/29/1983
• Issued: 11/12/1985
• Est. Priority Date: 01/07/1983
• Status: Expired due to Fees

• Current Assignee: Cordis Europa NV (Johnson & Johnson)
• Original Assignee: Cordis Europa NV (Johnson & Johnson)
• Inventors: Van Der Velden, Paulus M.
• Primary Examiner(s): Tung, T.
• Application Number:
  US06/566,576
• Time in Patent Office: 684 Days
• Field of Search: 204/1 T, 204/1 H, 204/433, 204/435
• US Class Current: 205/787.5
• CPC Class Codes: G01N 27/301 Reference electrodes

Abstract

A new reference electrode assembly is provided that includes a hydrogen ion specific electrode which is encapsulated in a polymer matrix. The bulk of the polymer matrix has an open cell structure within which a liquid is contained as the electrode potential producing agent, while its surface is such that it forms a barrier preventing a free and open connection to the environment of the reference electrode. The reference electrode assembly is especially suitable for in vivo measurements, and it may be designed so that it is substantially insensitive to pH variations of the solution being measured by the instrument of which the reference electrode assembly is a part.

Claims

1. A reference electrode assembly, comprising:

an ion-specific electrode, said electrode being encapsulated within and contacted by a polymer matrix, said polymer matrix being a weak electrolyte having a strong affinity for hydrogen ions, the bulk of said polymer matrix having an open cell structure which contains a liquid as an electrode potential causing agent and its surface being such that it forms a barrier preventing a free and open connection to the environment of the reference electrode, said polymer matrix being within a support member, wherein said ion-specific electrode is a hydrogen ion-specific electrode.

2. The reference electrode assembly according to claim 1, wherein the hydrogen ion-specific electrode is an iridium/iridium oxide wire electrode.

3. The reference electrode assembly according to claim 1, wherein the polymer matrix is prepared from cellulose acetate.

4. The reference electrode assembly according to claim 1, wherein the hydrogen ion-specific electrode is an iridium/iridium oxide pH wire electrode, and wherein the polymer matrix is a blood compatible polymer matrix.

5. The reference electrode assembly according to claim 1, wherein the polymer matrix includes a pH buffer material.

6. The reference electrode assembly according to claim 1, wherein the hydrogen ion-specific electrode is an iridium/iridium oxide pH wire electrode and the polymer matrix is a cellulose acetate matrix.

7. The reference electrode assembly according to claim 1, wherein the support member includes an opening for access to fluids being monitored.

8. A method for monitoring the pH of fluids, comprising:

encapsulating a hydrogen ion-specific electrode within a polymer matrix which has an open cell structure and a barrier surface, said encapsulating including contacting the electrode with the polymer matrix, and said polymer matrix being a weak electrolyte having a strong affinity for hydrogen ions;

contacting a portion of the polymer matrix with a fluid to be monitored;

diffusing the ions in the fluid through the polymer matrix and to the hydrogen ion-specific electrode; and

measuring a parameter of the fluid by utilizing the hydrogen ion-specific electrode within the polymer matrix as a reference electrode.

9. The method of claim 8, wherein said encapsulating step includes filling a support member with a cellulose acetate solution and coagulating same into a matrix.

10. The method of claim 8, wherein said contacting step includes subcutaneous application.

11. The method of claim 8, wherein the polymer matrix is prepared from cellulose acetate.

12. The method of claim 8, wherein the hydrogen ion-specific electrode is an iridium/iridium oxide pH wire electrode.

13. The method of claim 8, further including incorporating a pH buffering material into the polymer matrix.