Gonadoliberin derivatives process for the preparation and pharmaceutical compositions thereof
First Claim
1. A compound of the Formula (I)
whereinX represents a D-thyroxyl or D-thyronyl group, andY stands for a glycine-amide group or an --NH-alkyl group containing 1 to 4 carbon atoms in the alkyl moiety, or a pharmaceutically acceptable acid addition salt or metal complex thereof.
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Accused Products
Abstract
The invention relates to new gonadoliberin derivatives of the formula (I)
Glp-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y, (I)
wherein
Y represents a glycine-amide group or an -NH-alkyl group having 1 to 4 carbon atoms in the alkyl moiety,
X stands for a D-thyroxyl, D-thyronyl or D-4-chlorophenylalanyl group,
and acid addition salts and metal complexes thereof.
The new nona- and decapeptide derivatives have an excellent luteinizing and folliculus stimulating hormone releasing activity, and they can therefore be used as active ingredients in pharmaceutical compositions for human or veterinary application.
102 Citations
6 Claims
- 1. A compound of the Formula (I)
- space="preserve" listing-type="equation">Glp-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y (I)
wherein X represents a D-thyroxyl or D-thyronyl group, and Y stands for a glycine-amide group or an --NH-alkyl group containing 1 to 4 carbon atoms in the alkyl moiety, or a pharmaceutically acceptable acid addition salt or metal complex thereof. - View Dependent Claims (2, 3, 4, 5, 6)
- 3. The compound of the Formula (I) defined in claim 1 which is
- space="preserve" listing-type="equation">Glp-His-Trp-Ser-Tyr-D-Thx-Leu-Arg-Pro-Gly-NH.sub.2
or a pharmaceutically acceptable acid addition salt or metal complex thereof.
Specification