Process for preparing osmotic device
First Claim
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1. A process for making an osmotic delivery system for delivering a beneficial drug to an environment of use, said process comprising:
- (a) compressing a drug formulation into a solid mass of drug;
(b) coating the solid mass of drug with a wall-forming composition comprising (1) ethyl cellulose (2) a polyhydroxy polymer member selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, and hydroxyethyl cellulose, and (3) a carboxypolymer selected from the group consisting of carboxypolymethylene, poly(methylvinylether maleic anhydride), ethylene-acrylic acid copolymer, ethylene maleic acid anhydride copolymer, and methacrylic acid-ethylacrylic acid copolymer;
(c) reacting the polyhydroxy polymer and the carboxypolymer by heating the coated solid mass of drug to a temperature sufficient to cause the polyhydroxy polymer and the carboxypolymer to react and from with the ethyl cellulose a wall surrounding the solid mass of drug;
(d) cooling the wall surrounded solid mass of drug to room temperature; and
,(e) drilling a passageway through the wall for delivering the drug formulation from the delivery system.
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Abstract
An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.
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5 Claims
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1. A process for making an osmotic delivery system for delivering a beneficial drug to an environment of use, said process comprising:
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(a) compressing a drug formulation into a solid mass of drug; (b) coating the solid mass of drug with a wall-forming composition comprising (1) ethyl cellulose (2) a polyhydroxy polymer member selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, and hydroxyethyl cellulose, and (3) a carboxypolymer selected from the group consisting of carboxypolymethylene, poly(methylvinylether maleic anhydride), ethylene-acrylic acid copolymer, ethylene maleic acid anhydride copolymer, and methacrylic acid-ethylacrylic acid copolymer; (c) reacting the polyhydroxy polymer and the carboxypolymer by heating the coated solid mass of drug to a temperature sufficient to cause the polyhydroxy polymer and the carboxypolymer to react and from with the ethyl cellulose a wall surrounding the solid mass of drug; (d) cooling the wall surrounded solid mass of drug to room temperature; and
,(e) drilling a passageway through the wall for delivering the drug formulation from the delivery system. - View Dependent Claims (2, 3, 4, 5)
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Specification