Synthetic wound covering

• US 4,554,317 A
• Filed: 10/06/1983
• Issued: 11/19/1985
• Est. Priority Date: 04/06/1982
• Status: Expired due to Term

• Current Assignee: BEN-HUR, NAHUM - 30%, The State of Israel Atomic Energy Commission Soreq Nuclear Research/Center
• Original Assignee: BEN-HUR, NAHUM - 30%, The State of Israel Atomic Energy Commission Soreq Nuclear Research/Center
• Inventors: Behar, David, Ben-Hur, Nahum, Rajbenbach, Arie L., Juszynski, Marta
• Primary Examiner(s): Hoke, Veronica P.
• Application Number:
  US06/539,586
• Time in Patent Office: 775 Days
• Field of Search: 128/156, 204/159.19, 525/28, 525/454, 424/26, 424/28, 424/78
• US Class Current: 424/443
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A synthetic hydrophilic membrane is prepared by graft polymerization of hydrophilic monomers with a polyurethane substrate. The resulting material has a water permeability in the range from about 1,000 to 8,000 g/m² /24hr. The material is particularly useful as a wound covering material where such water permeability corresponds to the elevated water loss from open wounds and allows the wound to heal without desiccation or water accumulation under the covering.

Claims

1. A synthetic wound covering comprising a hydrophilic membrane which is a graft polymer formed from a polyester polyurethane substrate having a modulus of elasticity below 1500 PSI and a hydrophilic acrylamide monomer wherein the monomer is present at at least 50% by weight and is substantially uniformly dispersed through the substrate, whereby the graft polymer has a water permeability in the range from 1000 to 8000 g/m² /24 hr and a modulus of elasticity below about 600 PSI when wet.

2. A synthetic wound covering according to claim 1, having a thickness in the range from 10 to 100 microns.

3. A synthetic wound covering according to claim 1, wherein the polyurethane is a polyester polyurethane having a recurring unit of the formula

4. A synthetic wound covering according to claim 3, wherein average n is from 2.5 to 8.

5. A synthetic wound covering according to claim 3, wherein R₁ and R₂ are each a tetramethylene group --(CH₂)₄ --.

6. A wound covering material comprising a graft polymer formed from a polyester polyurethane substrate having a modulus of elasticity below 1500 PSI and a hydrophilic acrylamide monomer present at at least 50% by weight, said material having a water permeability in the range from 1,000 to 8,000 g/m² /24 hr and a modulus of elasticity below 600 PSI when wet, wherein said covering is sterilized and enclosed in a sealed package.

7. A wound covering material as in claim 6, having a drug uniformly dispersed at about from 0.001 to 2 weight percent.

8. A method for treating a wound, said method employing a wound covering material comprising a graft polymer formed from a polyester polyurethane substrate having a modulus of elasticity below about 1500 PSI and a hydrophilic acrylamide monomer present at at least 50% by weight, said material having a water permeability in the range from 1000 to 8,000 g/m² /24 hr and modulus of elasticity below 600 PSI when wet, said method comprising:

applying the covering material to the wound such that the covering conforms to the surface of the wound.

9. A method as in claim 8, wherein the covering is dry when applied to the wound.

10. A method as in claim 8 wherein the covering is wetted prior to applying to the wound.

11. A method as in claim 8, wherein the covering material is secured to the wound by external means.

12. A process for preparing an elastic hydrophilic membrane, said process comprising graft polymerizing a hydrophilic acrylamide monomer onto a Polyeater polyurethane substrate, wherein said substrate has a modulus of elasticity in the range from 150 to 1500 PSI and the polymerization is continued for an amount of time sufficient to yield a product having at least 50 weight percent hydrophilic acrylamide monomer and a water permeability in the range from 1,000 to 8,000 g/m² /24 hr.

13. A process as in claim 12, wherein graft polymerization is initiated by radiation.

14. A process as in claim 12, wherein graft polymerization is chemically initiated by a cerium salt.

15. A process for preparing an elastic hydrophilic membrane, said process comprising:

preparing a reaction medium having preselected concentrations of a hydrophilic acrylamide monomer and a homopolymerization inhibitor;

immersing a polyester polyurethane substrate in the reaction medium, said substrate having a modulus of elasticity in the range from 150 to 1500 PSI; and

initiating graft polymerization between the monomer and the substrate and continuing such polymerization for a time sufficient to cause a weight increase of at least 50% relative to the initial weight of the substrate and the resulting hydrophilic membrane attains a water permeability in the range from 1,000 to 8,000 g/m² /24 hr.

16. A process as in claim 15, wherein the polyester polyurethane substrate has an elongation at break of at least 500%.

17. A process as in claim 15, wherein the polyester polyurethane has a recurring unit of the formula:

space="preserve" listing-type="equation">(OR.sub.1 OCOR.sub.2 CO).sub.n OR.sub.1 OCONH--C.sub.6 H.sub.4 --CH.sub.2 --C.sub.6 H.sub.4 --NHCO

in which R₁ and R₂ may be the same or different and are each a group --(CH₂)_x -- where x is an integer of 1 to 8 and n has an average value of 2.5 to 20.

18. A process as in claim 15, wherein the homopolymerization inhibitor is a transition metal salt.

19. A process as in claim 18, wherein the transition metal salt is cerium salt.

20. A process as in claim 18, wherein the transition metal salt a ceric ammonium nitrate.

21. A hydrophilic membrane produced in accordance with the method of claim 15.